Technology of Fine Chemicals and Bulk drugs detailed syllabus for Pharmacy (Pharma) for 2021 regulation curriculum has been taken from the Anna Universities official website and presented for the Pharma students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Pharmacy 5th Sem scheme and its subjects, do visit Pharma 5th Sem 2021 regulation scheme. For Professional Elective-II scheme and its subjects refer to Pharma Professional Elective-II syllabus scheme. The detailed syllabus of technology of fine chemicals and bulk drugs is as follows.
Course Objectives:
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Unit I
INTRODUCTION OF FINE CHEMICALS AND BULK DRUGS 9
Concept of fine and Bulk drugs and their salient features – Evolution of process – Process chemistry – Research and development strategies in pharmaceutical industries, Chemical process life cycle, Legislative requirements for safe process development and scale up.
Unit II
PRODUCTION, PLANNING AND CONTROL 9
Flow sheets – Types of flow sheets – Flow symbols – Line symbols – Concept of all purpose and multipurpose plants – Plant design – Layout –– Process economics – Materials of construction – Effluent minimization and control and solvent recovery for fine chemicals and bulk drugs.
Unit III
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Unit IV
BASE CHEMICALS, DRUG INTERMEDIATES AND FINE CHEMICAL
PRODUCTION 9
Manufacture of following chemicals and their applications – Sulphuric acid – Caustic soda – Ammonia – Phenol – Industrial alcohol – Urea – Acrylonitrile –Ethyl acetate – Butadiene – Aniline – Titanium dioxide –Vanillin.
Unit V
BULK DRUGS PRODUCTION 9
Raw Materials – Production Techniques – Reaction Flow Sheet – Equipments Utilities for the production of drugs below – Paracetamol – Aspirin – Ibuprofen – Diazepam, Vitamin C – Salbutamol – Ranitidine – Sulphamethoxazole – Cephalosporins – Erythromycin, Chloramphenicol, Sulfathiazole .
Course Outcomes:
The student will be able to
- Apply legislative requirements and obtain official approval of the regulatory authorities for safe process development and scale up of fine chemicals and bulk drugs industries.
- Demonstrate the importance of flow sheets, flow symbols, plant design, layout and plant construction materials for the production of bulk drugs and fine chemicals and to implement the concept of effluent treatment and solvent recovery in pharmaceutical industries
- Develop and optimize the best synthetic scheme and pilot plant procedure to manufacture compounds and to insist development techniques for safe process considering the hazard assessment
- Apply the knowledge of process chemistry in the production techniques of fine chemicals.
- Analyze the different process involved in bulk drug manufacturing chemical and manufacturing processes associated with the production of small molecule drugs.
- Understand and apply the kinetics, thermodynamics and the concept of process economics in multipurpose plants
Text Books:
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Reference Books:
- A. Cybulski, ” Fine Chemicals Manufacture- Technology and Engineering Elsevier Publication, 2000
- Stanley Nusim, “Active Pharmaceutical Ingredients” Informa Healthcare, 2009
For detailed syllabus of all the other subjects of Pharmacy 5th Sem, visit Pharma 5th Sem subject syllabuses for 2021 regulation.
For all Pharmacy results, visit Anna University Pharma all semester results direct link.