Bioinformatics detailed syllabus for Biotechnology (BioTech) for 2021 regulation curriculum has been taken from the Anna University official website and presented for the BioTech students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Biotechnology 6th Sem scheme and its subjects, do visit BioTech 6th Sem 2021 regulation scheme. The detailed syllabus of bioinformatics is as follows.
Course Objectives:
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Unit I
BIOLOGICAL DATABASES 9
Introduction to Bioinformatics and Computational Biology, Biological sequences, Classification of biological databases – Sequence Databases, Structure Databases, Genome specific databases, Special Databases and applications- Microarray, Metabolic pathway, motif, and domain databases, Data file formats.
Unit II
SEQUENCE ANALYSIS 9
Sequence Alignment- Homology vs Similarity, Similarity vs Identity. Types of Sequence alignment -Pairwise and Multiple sequence alignment, Global alignment, Local alignment, Dotplot, Alignment algorithms- Needleman wunsch and Smith and waterman algorithm, Substitution matrices- PAM,
BLOSUM.Multiple Sequence Alignment- Application of multiple alignments, Viewing and editing of MSA and Scoring function.Database Similarity Searching- Basic Local Alignment Search Tool (BLAST), FASTA, PHI BLAST, PSI BLAST, BLAST algorithm.
Unit III
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Unit IV
MACROMOLECULAR STRUCTURE ANALYSIS 9
Gene prediction, Conserved domain analysis, Protein structure visualization, Prediction of protein secondary structure, Tertiary structure prediction- Homology modeling, Threading, Ab-initio prediction. Validation of the predicted structure using Ramachandran plot, steriochemical properties, Structure- structure alignment.
Unit V
APPLICATIONS 9
Introduction to Systems Biology and Synthetic Biology, Microarray data analysis, DNA computing, Bioinformatics approaches for drug discovery, Applications of Bioinformatics in genomics and proteomics- Assembling the genome, STS content mapping for clone contigs, Functional annotation, Peptide mass fingerprinting.
Course Outcomes:
Upon completion of this course, Student will be able to
- Use and describe bioinformatics data and information resources.
- Apply computational based solutions for biological perspectives
- Analyze the evolutionary relationship between the organisms
- Understand the macromolecules structure prediction methods
- Relate how bioinformatics methods can be used in sequence to structure and function analysis.
- Learn the applications of bioinformatics approach for drug discovery, genomics and proteomics.
Text Books:
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For detailed syllabus of all other subjects of Biotechnology, 2021 regulation curriculum do visit BioTech 6th Sem subject syllabuses for 2021 regulation.
For all Biotechnology results, visit Anna University BioTech all semester results direct link.