Biopharmaceutics and Pharmacokinetics detailed syllabus for Pharmacy (Pharma) for 2021 regulation curriculum has been taken from the Anna University official website and presented for the Pharma students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Pharmacy 7th Sem scheme and its subjects, do visit Pharma 7th Sem 2021 regulation scheme. The detailed syllabus of biopharmaceutics and pharmacokinetics is as follows.
Course Objectives:
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Unit I
DRUG ABSORPTION AND DISTRIBUTION 9
Mechanisms of drug absorption through GIT, factors influencing drug absorption through GIT, absorption of drug from Non-per oral extravascular routes, Distribution of drugs, Tissue permeability of drugs, binding of drugs, apparent volume of drug distribution, plasma and tissue protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs.
Unit II
ELIMINATION 9
Drug metabolism, metabolic pathways, factors affecting metabolism, renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non- renal routes of drug excretion of drugs.
Unit III
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Unit IV
PHARMACOKINETICS 9
Introduction to Pharmacokinetics, Pharmacokinetic models, One compartment open model Intravenous Bolus Injection – Intravenous infusion – Extra vascular administrations. Determination of pharmacokinetics parameters and their significance – Absorption Rate Constant (ka), Elimination Rate Constant (K) & Elimination Half- life (t½), AUC, Cmax, and tmax. Apparent Volume of Distribution (Vd) & Renal Clearance (Q).
Unit V
MULTIPLE DOSAGE REGIMENS AND NONLINEAR PHARMACOKINETICS 9
Concept, Accumulation, Persistent and elimination factors. Calculation of dosage regimen following repetitive IV and oral administration. Nonlinear Pharmacokinetics – Introduction, factors causing Non-linearity, Michaelis-menton method of estimating pharmacokinetic parameters.
Course Outcomes:
On completion of the course the students will be able to
- identify the factors affecting the rate of drug absorption.
- study the various factors influencing the drug disposition, various pharmacokinetic parameters.
- Estimate various pharmacokinetic parameters using plasma and urine drug level data.
- design and interpret the bioavailability and bioequivalence of dosage forms.
- Predict the effects of dosage form design and routes of drug administration on drug levels in the body.
- Demonstrate the technical skills acquired in the field of pharmaceutical technology
Text Books:
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Reference Books:
- Robert E Notari “Biopharmaceutics and Clinical Pharmacokinetics” 2019, Taylor & Francis ISBN -13 978-0367340797
- Shargel, L and Andrew, B.C. Yu. “Applied Biopharmaceutics & Pharmacokinetics”,7th Edition, The McGraw-Hill Companies, Inc, 2016.
- Gibaldi, M. “Biopharmaceutics & Clinical Pharmacokinetics”, 4th Edition, Pharma Book Syndicate, 2016.
- Jambhekar, S.S. and Philip, J. B. “Basic Pharmacokinetics” 2nd Edition, Pharmaceutical Press,2012
For detailed syllabus of all other subjects of Pharmacy, 2021 regulation curriculum do visit Pharma 7th Sem subject syllabuses for 2021 regulation.
For all Pharmacy results, visit Anna University Pharma all semester results direct link.