Pharmaceutical Chemistry Laboratory detailed syllabus for Pharmacy (Pharma) for 2021 regulation curriculum has been taken from the Anna University official website and presented for the Pharma students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Pharmacy 4th Sem scheme and its subjects, do visit Pharma 4th Sem 2021 regulation scheme. The detailed syllabus of pharmaceutical chemistry laboratory is as follows.
Course Objectives:
- To provide students with the practical laboratory skills of pharmaceutical chemistry
- To demonstrate the effect of the different synthetic methodology.
- To clarify theoretical concepts of chemical synthesis of drug molecules.
List of Experiments:
- To determine the strength of a given unknown solution of HCl by titrating it against with the help of a known solution of NaOH using phenolphthalein indicator.
- To determine the strength of a given unknown solution of NaOH by titrating it against with the help of a known solution of HCl using methyl orange indicator.
- To prepare and standardize 200 ml of 0.1 M silver nitrate solution.
- Determination of physical constants: melting point, boiling point, viscosity and pKa.
- Determination of partition coefficient of any medicinal compound by shake flask method.
- Preparation and identification tests of the following official (IP) compounds: Magnesium sulphate, Calcium Carbonate, Ferrous sulphate, Boric acid
- Determination of impurities by limit test
- Synthesis of compounds by hydrolysis reaction: Salicylic acid from Alkyl Benzoate.
- Synthesis of compounds by oxidation reaction: Benzoic acid from Benzyl chloride.
- Synthesis of compounds involving Electrophilic substitution reaction:
Benzoylation: Benzanilide, Phenyl benzoate, 2-Naphthyl benzoate
Acetylation: Aspirin
Nitration: Picric acid, p-nitro aniline, m – dinitro benzene
Halogenaion: p-bromo acetanilide
Haloform: Iodoform - Synthesis of compounds by naming reaction: 7- hydroxy -4- methyl coumarin (Pechmann reaction), 1- phenyl azo-2-napthol (Diazotization and Coupling reaction)
- Synthesis of major industrial compounds: Paracetamol from p-aminophenol, Benzocaine from p-nitro benzoic acid
List of Equipments:
REQUIRED FOR 30 STUDENTS
- Vacuum filtrationunit
- Refluxcondenser
- Hotair oven
- Waterbath
- Distillationunit
- Melting point apparatus
- pH meter
- Electronic Weighing balance
- Heating Mantle
- Vacuum dryer
Course Outcomes:
The students will be able to
- Apply safe laboratory practices in the preparation of reagents, handling and storage of chemicals.
- Identify/confirm the unknown organic compounds by melting point determination, pKa, boiling point, Viscosity etc.
- Carry out quality control tests for fine chemicals and bulk drugs.
- Implement the knowledge of chemistry in designing the synthetic scheme of organic compounds.
- Demonstrate feasible synthesis of some important class of drugs using chemical reactions.
- Develop the reaction mechanism and orientation of chemical bonds in the synthesis of major industrial compounds.
Reference Books:
- K.Yogananda Reddy, Dr.K.N. Jayaveera&Dr.S.Subramanyam, Practical Medicinal Chemistry, S.Chan Publishing, 2013
- Vogel’s Textbook of Practical Organic Chemistry, 5th edition, Pearson Publisher, 2003.
- Mann & Saunders, Practical Organic Chemistry, 4th edition, Pearson Publisher, 2009.
- Chatwal G.R, Pharmaceutical chemistry inorganic Himalaya publishing house, Ed5th, 2010, pp 127-128.
- N.M. Raghavendra &Sayan Dutta Gupta, Laboratory manual of Pharmaceutical Organic Chemistry- I, Vallabh Prakashan, 1st edition. 2013.
For detailed syllabus of all other subjects of Pharmacy, 2021 regulation curriculum do visit Pharma 4th Sem subject syllabuses for 2021 regulation.
For all Pharmacy results, visit Anna University Pharma all semester results direct link.