Biological spectroscopic techniques detailed syllabus for Pharmacy (Pharma) for 2021 regulation curriculum has been taken from the Anna Universities official website and presented for the Pharma students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Pharmacy 5th Sem scheme and its subjects, do visit Pharma 5th Sem 2021 regulation scheme. For Professional Elective-III scheme and its subjects refer to Pharma Professional Elective-III syllabus scheme. The detailed syllabus of biological spectroscopic techniques is as follows.
Course Objectives:
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Unit I
EXTRACTION OF DRUGS FROM THE BIOLOGICAL MATRIX 9
Introduction – types of samples – sampling – physicochemical properties of drug – sample pretreatment in different biological matrices – sample preparation – – methods of extraction – liquid liquid extraction – solid phase extraction – Protein precipitation method- solid phase microextraction.
Unit II
GAS CHROMATOGRAPHY 9
Principle of separation – criteria for compounds – carrier gas – flow regulatory – injection devices – column – temperature control device – detectors – recorders and integrators –parameters used in GC – Application of GC.
Unit III
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Unit IV
BIOANAYTICAL METHOD DEVELOPMENT AND VALIDATION 9
Key steps for analytical method development – General principles – ligand binding assays – incurred sample reanalysis – practical and cross validation – additional consideration.
Unit V
MICROSCOPIC TECHNIQUES AND HIGH THROUGHPUT SCREENING 9
Electron microscopy – transmission and scanning electron microscopy – scanning tunnelling and atomic force microscopy – combinatorial chemistry and high throughput screening methods.
Course Outcomes:
Upon completion of this course, the student would be able to
- Understand and demonstrate the separation of drugs from the biological matrix.
- Understand the basic principle and instrumentation methods of gas chromatography and its applications in pharmaceuticals.
- Describe the theory and operation of X-ray diffraction; Determination of crystal structure of drug molecule.
- Understand and demonstrate the key steps in analytical method development and validation.
- Apply the techniques in material science for research, quality control and analysis.
- Apply the theoretical knowledge of modern analytical tools, new screening methods for the estimation of micro and macro molecules.
Text Books:
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Reference Books:
- ICH Harmonized Guideline BIOANALYTICAL METHOD VALIDATION M10.
- Hammes, Gordon G. “Spectroscopy for the Biological Sciences”. John Wiley, 2005. 80
- Hobert H. Willard, “Instrumental Methods of Analysis”, 7th Edition,CBS Publishers & Distributors, 2004.
- Atkins P.W., “Physical Chemistry “,10th Edition, Oxford University Press India, 2014.
For detailed syllabus of all the other subjects of Pharmacy 5th Sem, visit Pharma 5th Sem subject syllabuses for 2021 regulation.
For all Pharmacy results, visit Anna University Pharma all semester results direct link.