Pharmacogenomics Pharma 6th Sem Syllabus for B.Tech 2017 Regulation Anna Univ (Professional Elective IV) detail syllabus for Pharmacy (Pharma), 2017 regulation is collected from the Anna Univ official website and presented for students of Anna University. The details of the course are: course code (PY8012), Category (PE), Contact Periods/week (3), Teaching hours/week (3), Practical Hours/week (0). The total course credits are given in combined syllabus.
For all other pharma 6th sem syllabus for b.tech 2017 regulation anna univ you can visit Pharma 6th Sem syllabus for B.Tech 2017 regulation Anna Univ Subjects. For all other Professional Elective IV subjects do refer to Professional Elective IV. The detail syllabus for pharmacogenomics is as follows.
Course Objective:
- The course intends to provide knowledge about pharmacogenomics and drug design using genomic applications for drug action and toxicity.
- To understand how individualization of drug therapy can be achieved based on a persons genetic makeup while reducing unwanted drug effects.
Unit I
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Unit II
Human Genome
Expressed sequence Tags (EST) and computational biology, Microbial genomics, computational analysis of whole genomes, computational genome analysis, Genomic differences that affect the outcome of host pathogen interactions, Protein coding genes, repeat elements, genome duplication, analysis of proteome, DNA variation, Biological complexity. Single nucleotide polymorphisms (SNPs) in Pharmacogenomics – approaches, number and types of SNPs, Study design for analysis, Analytical issues, Development of markers.
Unit III
Association Studies in Pharmacogenomics
Viability and Adverse drug reaction in drug response, Multiple inherited genetic factors influence the outcome of drug treatments, Association studies in pharmacogenomics, Strategies for pharmacogenomics Association studies, Benefits of Pharmacogenomics in Drug R and D.
Unit IV
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Unit V
Pharmacogenomics – Case Studies
Study of pharmacogenomics of human P-Glycoprotein, drug transporters, lipid lowering drugs, chemotherapeutic agents for cancer treatment.
Course Outcome:
At the completion of course, the student will be able to
- Distinguish the effect of genetic differences between individuals in the outcome of drug therapy and in drug efficacy and toxicity.
- Describe the role of single nucleotide polymorphism as a biomarker for the prediction of risk, therapeutic response and prognosis of malignancies.
- Utilize and manage the new genomics based tools as they become available as well as make best treatment choices.
Text Books:
- Martin M. Zdanowicz, M.M. Concepts in Pharmacogenomics Second Edition, American Society of Health-System Pharmacists, 2017.
- Licinio, J and Wong, Ma-Li. Pharmacogenomics: The Search for the Individualized Therapies, Wiley-Blackwell, 2009.
- Yan Q, Pharmacogenomics in Drug Discovery and Development Humana Press, 2nd Edition, 2014.
References:
- Brazeau, D.A. and Brazeau, G.A. Principles of the Human Genome and Pharmacogenomics American Pharmacist Association, 2011
- Werner, K., Meyer, U.A., Tyndale, R.F. Pharmacogenomics, Second Edition, Taylor and Francis, 2005.
- Langman, L.J. and Dasgupta, A. “Pharmacogenomics in Clinical Therapeutics”, Wiley -Blackwell, 2012
For detail syllabus of all other subjects of B.Tech Pharma, 2017 regulation do visit Pharma 6th Sem syllabus for 2017 Regulation.
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