Metabolic Engineering Biotech 6th Sem Syllabus for B.Tech 2017 Regulation Anna Univ (Professional Elective IV) detail syllabus for Biotechnology (Biotech), 2017 regulation is collected from the Anna Univ official website and presented for students of Anna University. The details of the course are: course code (BT8013), Category (PE), Contact Periods/week (3), Teaching hours/week (3), Practical Hours/week (0). The total course credits are given in combined syllabus.
For all other biotech 6th sem syllabus for b.tech 2017 regulation anna univ you can visit Biotech 6th Sem syllabus for B.Tech 2017 regulation Anna Univ Subjects. For all other Professional Elective IV subjects do refer to Professional Elective IV. The detail syllabus for metabolic engineering is as follows.
Course Objective:
- To provide a quantitative basis, based on thermodynamics, enzyme kinetics, for the understanding of metabolic networks in single cells and at the organ level.
- To enable the students to use organisms to produce valuable substances on an industrial scale in cost effective manner.
Unit I
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Unit II
Material Balances and Data Consistency
Comprehensive models of cellular reactions; stoichiometry of cellular reactions, reaction rates, dynamic mass balances, yield coefficients and linear rate equations, analysis of over determined systems- identification of gross measurement errors. Introduction to MATLAB
Unit III
Metabolic Flux Analysis
Theory, overdetermined systems, underdetermined systems- linear programming, sensitivity analysis, methods for the experimental determination of metabolic fluxes by isotope labeling, applications of metabolic flux analysis.
Unit IV
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Unit V
Analysis of Metabolic Networks
Control of flux distribution at a single branch point, Grouping of reactions, case studies, extension of control analysis to intermetabolite, optimization of flux amplifications, consistencytests and experimental validation.
Course Outcome:
After completion of metabolic engineering, students will be able
- To learn stoichiometry and energetics of metabolism.
- To apply practical applications of metabolic engineering in chemical,energy,medical and environmental fields.
- To integrate modern biology with engineering principles.
- To design a system, component, or process to meet desired needs.
Text Books:
- Gregory N. Stephanopoulos ,Aristos A. Aristidou, Jens Nielsen, Metabolic Engineering: Principles and Methodologies ,Academic Press 1998.
- Sang Yup Lee E. Terry Papoutsakis Marcel Dekker, Metabolic Engineering.inc 1998
- Nielsen J and Villadsen J. (1994) Bioreaction Engineering Principles. New york: Plenum Press
References:
- Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists by Eberhard O. Voit Cambridge University Press 2000
- Applications of Plant Metabolic Engineering. R. Verpoorte, A. W. Alfermann and T. S. Johnson (eds). Springer, P.O. Box 17, 3300 AA Dordrecht, The Netherlands. 2007.
- Systems Modeling in Cellular Biology: From Concepts to Nuts and Bolts Edited by Zoltan Szallasi, JorgStelling and VipulPeriwal MIT Press Cambridge 2006
For detail syllabus of all other subjects of B.Tech Biotech, 2017 regulation do visit Biotech 6th Sem syllabus for 2017 Regulation.
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