Advanced Medicinal Chemistry Pharma 6th Sem Syllabus for B.Tech 2017 Regulation Anna Univ (Professional Elective IV) detail syllabus for Pharmacy (Pharma), 2017 regulation is collected from the Anna Univ official website and presented for students of Anna University. The details of the course are: course code (PY8010), Category (PE), Contact Periods/week (3), Teaching hours/week (3), Practical Hours/week (0). The total course credits are given in combined syllabus.
For all other pharma 6th sem syllabus for b.tech 2017 regulation anna univ you can visit Pharma 6th Sem syllabus for B.Tech 2017 regulation Anna Univ Subjects. For all other Professional Elective IV subjects do refer to Professional Elective IV. The detail syllabus for advanced medicinal chemistry is as follows.
Course Objective:
The content of this syllabus is designed
- To understand the role of enzyme induction and inhibition for drug biotransformation
- To cater essential features of pharmacophores to enable a ligand molecule to interact with a specific target receptor.
- To understand the mode of action and structure activity relationship of Chemotherapeutic agents, Amino acids, peptide, nucleotides and related drugs and Steroids and related drugs
Unit I
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Unit II
Pharmacophore Concept
Methods of conformational search used in pharmacophore mapping. Comparison between the popular pharmacophore methods like Catalyst/HipHop, DiscoTech, GASP with practical examples. De Novo drug design techniques: Receptor/enzyme cavity size prediction. Predicting the functional components of cavities, designing drugs fitting into cavity.
Unit III
Chemotherapeutic Agents
Synthetic procedures of selected drugs, mode of action, uses, structure activity relationship including Physico-Chemical properties of Antitubercular, Antimalarial, Antifungal, and Antiamoebic drugs.
Unit IV
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Unit V
Steroids and Related Drugs
Synthetic procedures of selected drugs, mode of action, uses, structure activity relationship including Physico-Chemical properties of the following classes of drugs Steroidal nomenclature
and stereochemistry, androgens and anabolic agents, estrogens, and progestational agents, adrenocorticoids.
Course Outcome:
- The student would be equipped with the advanced knowledge of identification of different targets in different diseases.
- The student will be able to involve in drug discovery programmes including lead identification, design of pro drug and their metabolic pathways.
- The student will be able to interpret structure-activity relationships and fundamental principles governing the molecular interactions of a drug with its target.
Text Books:
- Donald J. Abraham, David P. Rotella (Eds.,), Burgers Medicinal Chemistry and Drug Discovery, Vol. I-VIII, 7th Edition, John Wiley and Sons, Inc., New Jersy, 2010.
- Wilson and Gisvold, Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th Edition, Lippincott Williams and Wilkins -Philadelphia, 2010.
- William O Foye, Thomas L Lemke, David A Williams Foyes Principles of Medicinal Chemistry, 7th Edition, Wolters Kluwer Health Adis (ESP) Publisher, 2012.
- Daniel Lednicer, Lester A. Mitscher (Eds.), The Organic Chemistry of Drug Synthesis, Vol. I-VII, Wiley Publisher, 2007.
References:
- Ariens, Drug Design: Medicinal Chemistry, Volume I-X, Academic Press, 2009.
- Corwin, Hansen, Comprehensive Medicinal Chemistry III, 3rd Edition, Elsevier, 2017.
- Richard B. Silvermann, Mark W. Holladay, The Organic Chemistry of Drug Design and Drug Action 3rd Edition, Academic Press, 2014.
- H. John Smith, Hywel Williams, Introduction to principles of Drug Design, CRC Press, 2005.
- Camille Wermuth, David Aldous, Pierre Raboisson, Didier Rognan, The Practice of Medicinal Chemistry, 4th Edition, Elsevier Publications, 2001
For detail syllabus of all other subjects of B.Tech Pharma, 2017 regulation do visit Pharma 6th Sem syllabus for 2017 Regulation.
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