Structural Biology Biotech 6th Sem Syllabus for B.Tech 2017 Regulation Anna Univ (Professional Elective IV) detail syllabus for Biotechnology (Biotech), 2017 regulation is collected from the Anna Univ official website and presented for students of Anna University. The details of the course are: course code (BT8015), Category (PE), Contact Periods/week (3), Teaching hours/week (3), Practical Hours/week (0). The total course credits are given in combined syllabus.
For all other biotech 6th sem syllabus for b.tech 2017 regulation anna univ you can visit Biotech 6th Sem syllabus for B.Tech 2017 regulation Anna Univ Subjects. For all other Professional Elective IV subjects do refer to Professional Elective IV. The detail syllabus for structural biology is as follows.
Course Objective:
To enable the students:
- Gain structural knowledge on proteins.
Understand energetics and kinetics of proteins.
Unit I
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Unit II
Protein Thermodynamics and Energetics
Driving forces in protein folding – Estimation of solvation free energies: Group contribution methods -Experiments on folding thermodynamics – Two-state and multiple state transitions.
Unit III
Protein Kinetics
Mechanism of folding – Kinetic Intermediates – Classical kinetic modelling of protein folding/unfolding -Transition states – Effects of mutations.
Unit IV
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Unit V
Computational Structural Biology
Protein Models: Force fields and their derivation – The rugged energy surface: the difficulty to fold a protein – Methods for conformational search – energy and free energy as criteria of stability.
Course Outcome:
Upon completion of this course, students will:
- Be familiar with various mechanisms and driving forces in protein folding.
- Understand the dynamics relationship to protein function.
- Identify the computational approach in structural biology.
Text Books:
- Liljas L, Nissen P, Lindblom G, Textbook of Structural Biology, Volume 8 of Series in structural biology, World Scientific, 2016.
- Schwede T, Computational Structural Biology: Methods and Applications, World Scientific, 2008.
References:
- Liljas A, Textbook of Structural Biology, World Scientific, 2009.
- Petsko G, Ringe D, Protein structure and Function, Oxford University Press, 2009.
- K.P.Murphy. Protein structure, stability and folding (2001) Humana press. ISBN 0-89603682-0
- Arthur M.Lesk Introduction to protein architechcture (2001) Oxford University Press. ISBN 0198504748
- A.McPherson, Introduction to Macromolecular Crystallography. 2nd edition (2009)., John Wiley Co.
- Carl Branden and John Tooze and Carl Brandon Introduction to Protein Structure, (1999)
For detail syllabus of all other subjects of B.Tech Biotech, 2017 regulation do visit Biotech 6th Sem syllabus for 2017 Regulation.
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