Instrumental Techniques in Drug Analysis detailed syllabus for Pharmacy (Pharma) for 2021 regulation curriculum has been taken from the Anna University official website and presented for the Pharma students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Pharmacy 6th Sem scheme and its subjects, do visit Pharma 6th Sem 2021 regulation scheme. The detailed syllabus of instrumental techniques in drug analysis is as follows.
Course Objectives:
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Unit I
UV-VISIBLE SPECTROSCOPY 9
Theory of atomic and molecular spectra, Electronic transitions, Beer and Lambert’s law, Derivation and deviations, Chromophores, Auxochromes, Spectral shifts, Solvent effect on absorption spectra. Instrumentation – Sources of radiation, wavelength selectors, sample cells, Detectors-Barrier layer cell, Photo tube, PMT, PDA detectors; Applications in pharmaceuticals.
Unit II
ATOMIC ABSORPTION SPECTROSCOPY 9
Principles, Instrumentation, Operation – single and double beam spectroscopy; sampling technique – Detection limit, Difference between Atomic absorption spectroscopy and Flame spectroscopy; Applications in pharmaceuticals.
Unit II
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Unit IV
MASS SPECTROMETRY 9
Basic principles, instrumentation and ionization methods; atmospheric pressure ionization (API), chemical ionization (CI), electron impact ionization (EI), fast atom bombardment (FAB), matrix assisted laser desorption ionization (MALDI), time of flight (TOF); Applications in pharmaceuticals.
Unit V
CHROMATOGRAPHIC METHODS 9
History, origin and classification of chromatography: Column Chromatography: principle, theory, column operations, instrumentation, derivatisation methods and applications; High Performance
Liquid Chromatography: Principle, instrumentation, solvents system, packing materials and applications; Thin Layer Chromatography: Principle, instrumentation, solvents, packing materials and applications in pharmaceuticals.
Course Outcomes:
At the end of the course the students will be able to,
- Discuss the principle, theory and instrumentation of UV/Visible spectroscopy; Applications in pharmaceuticals.
- Describe the principle, instrumentation and operation of AAS; Difference between AAS and FES; Applications in pharmaceuticals.
- Illustrate the principle and instrumentation of IR and NMR spectroscopy; Applications in pharmaceuticals.
- Discuss the basic principle, instrumentation and ionization methods of Mass spectroscopy; Applications in pharmaceuticals.
- Describe the principle, instrumentation, solvents and packing materials of CC, TLC and HPLC; Applications in pharmaceuticals.
- Apply the theoretical knowledge of instruments, new analytical methods may be developed and validated for the screening of various pharmaceutical agents.
Text Books:
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Reference Books:
- Robert M. Silverstein, Francis X .Webster, David J. Kiemle,David L . Bryce, “Spectroscopic Identification of Organic Compounds”, 8th Edition, Wiley, 2014.
- Mendham J, “Vogel’s Text Book of Quantitative Chemical Analysis”, 6th Edition, Pearson Education 2009.
- Douglas A. Skoog, F. James Holler, Stanley R. Crouch, “Principles of Instrumental Analysis”, 7th Edition, Brooks Cole, 2017.
- William Kemp, “Organic Spectroscopy” W.H. Freeman, New York, 3rd Edition, 2011.
For detailed syllabus of all other subjects of Pharmacy, 2021 regulation curriculum do visit Pharma 6th Sem subject syllabuses for 2021 regulation.
For all Pharmacy results, visit Anna University Pharma all semester results direct link.