Protein Structure, Function and Proteomics detailed syllabus for Pharmacy (Pharma) for 2021 regulation curriculum has been taken from the Anna Universities official website and presented for the Pharma students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Pharmacy 5th Sem scheme and its subjects, do visit Pharma 5th Sem 2021 regulation scheme. For Professional Elective-I scheme and its subjects refer to Pharma Professional Elective-I syllabus scheme. The detailed syllabus of protein structure, function and proteomics is as follows.
Course Objectives:
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Unit I
PROTEIN STRUCTURE 9
Amino Acids Structure and Properties – Peptide Bond Formation and Primary Protein Structure -Secondary Protein Structure – Supersecondary Structure and Protein Motifs – Tertiary and Quaternary Protein Structure – Protein Folding, Denaturation and Hydrolysis.
Unit II
INVESTIGATING PROTEINS
Protein Purification – Protein Identification and Visualization – Protein Synthesis and Sequencing -Protein Structure Elucidation – Proteome Analysis
Unit III
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Unit IV
TECHNIQUES IN DETERMINING PROTEIN STRUCTURE AND FUNCTION 9
Structure-function relations – Protein Fluorescence Spectroscopy – Protein Circular Dichroism Spectroscopy – Protein EPR spectroscopy – Protein NMR Spectroscopy – Protein X-ray crystallography.
Unit V
PROTEOMICS 9
Introduction to the concept of proteome, components of proteomics, proteomic analysis, importance of proteomics in biological functions, protein arrays, cross linking methods, affinity methods, yeast hybrid systems and protein arrays. Self study (not for examination): Virtual labs and E-learning proteomics tools.
Text Books:
- Branden C. and Tooze J., “Introduction to Protein Structures” 2nd Edition, Garland Publishing, 1999’
- Creighton T.E. “Proteins” 2nd Edition. W.H. Freeman, 1993.
- Pennington, S.R and M.J. Dunn, “Proteomics: Protein Sequence to Function”. VivaBooks, 2002.
- Peptides and Proteins, RSC – ROYAL SOCIETY OF CHEMISTRY, SHAWN DOONAN
- Proteins Biochemistry and Biotechnology Second Edition Gary Walsh Wiley Blackwell.
- Recent review articles from peer reviewed journals.
Reference Books:
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Course Outcomes:
Students completing this course will
- have a foundational level of understanding of the principles of protein structure-dynamics-function relations
- explain the molecular principles behind the structure of proteins
- describe entropy – enthalpy compensation in macromolecular systems and how it controls stability and structural properties
- have a foundational level of understanding of multiple techniques that are collectively used to determine structures of dynamic protein complexes (NMR, cryo-electron microscopy, small angle X-ray scattering)
- understand selective pressure at the level of protein structure and dynamics in the evolution of new functions
- gain experience reading and critically discussing original literature in this field
For detailed syllabus of all the other subjects of Pharmacy 5th Sem, visit Pharma 5th Sem subject syllabuses for 2021 regulation.
For all Pharmacy results, visit Anna University Pharma all semester results direct link.