PM5611: Pharmacology Laboratory Syllabus for Pharma Tech 6th Sem 2019 Regulation Anna University

Pharmacology Laboratory detailed syllabus for Pharmaceutical Technology (Pharma Tech) for 2019 regulation curriculum has been taken from the Anna Universities official website and presented for the Pharma Tech students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.

For Pharmaceutical Technology 6th Sem scheme and its subjects, do visit Pharma Tech 6th Sem 2019 regulation scheme. The detailed syllabus of pharmacology laboratory is as follows.

Course Objective:

The course aims to,

• learn and understand the pharmacological aspects of drugs action
• correlate and apply the knowledge for drug development and evaluation.

List of Experiments:

1. Experiments on humane handling of animals for research (Eg. Mice, Rats, Jirds/Gerbils, rabbits, chickens)
2. Preparation and study of physiological salt solutions and laboratory appliances used in experimental pharmacology.
3. Bioassay experiments – study of the effects of various drugs on isolated tissues (heart, muscle etc., from abattoir specimens or nematodes) e.g Ach, adrenaline, effect of adrenergic and cholinergic blockers, effect of ions (through direct/audiovisual demonstration)
4. Experiments of drug evaluation using zebrafish model (Eg. Teratogenic effects, etc.,)
5. Experiments of drug evaluation using C.elegans model
6. Evaluation of pyrogens by in vitro LAL test (Limulus Amebocyte Lysate) test (or Limulus clotting factor C)
7. Routes of drug administration in animal models (through direct/audiovisual demonstration)
8. Experiments to study general anaesthetic effects of drugs
9. Experiments to study analgesic effects of drugs
10. Experiments to study local anaesthetic effects of drugs
11. Experiments to study anti-inflammatory effects of drugs
12. Experiments to study antiparasitic drugs (in-vitro /in-vivo methods using nematodes)
13. Experiments to study anticancer drugs by cytotoxic assay (MTT assay)

Equipments Required:

1. Animal House facility
2. UV-Visible spectrophotometer
3. Simulation softwares
4. Fish tanks, E.coli cultures C.elegans
5. Relevant consumables and drugs

Course Outcome:

At the end of the course the students will be able to,

1. be familiar with various animal handling techniques
2. study the pharmacological effects in different in-vitro, in-situ, in-vivo, in-silico organ systems
3. learn evaluation of drug effects through physiological models

Text Books:

1. Handbook of experimental pharmacology by S.K.Kulkarni, Vallabh Prakashan, 2014.
2. Pharmacological experiments on intact preparations by Churchill Livingstone.1970

References:

1. The Pharmacological basis of therapeutics – Goodman and Gilman”s, McGraw-Hill Education / Medical; 13 edition, 2017.
2. Fundamentals of experimental pharmacology by M.N.Ghosh, Hiltol and company, 6th edition, 2008.
3. https://zfin.org/ (The Zebrafish Information Network)
4. https://www.wormbase.org (Explore Worm Biology facilitating insights into nematode biology for research)

For detailed syllabus of all other subjects of Pharmaceutical Technology, 2019 regulation curriculum do visit Pharma Tech 6th Sem subject syllabuses for 2019 regulation.

For all Pharmaceutical Technology results, visit Anna University Pharma Tech all semester results direct link.