Fundamentals of Molecular Pathology detailed syllabus for Pharmaceutical Technology (Pharma Tech) for 2019 regulation curriculum has been taken from the Anna Universities official website and presented for the Pharma Tech students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Pharmaceutical Technology 5th Sem scheme and its subjects, do visit Pharma Tech 5th Sem 2019 regulation scheme. For Professional Elective-I scheme and its subjects refer to Pharma Tech Professional Elective-I syllabus scheme. The detailed syllabus of fundamentals of molecular pathology is as follows.
Course Objective:
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Unit I
Introduction
Molecular Koch”s postulates, Concepts of disease, Virulence, Optimal virulence, Horizontal and vertical transfer of virulent gene, Virulent factors, Evolution of bacterial pathogens, Biofilms, Quorum sensing molecules, Multidrug resistance mechanisms, Plasmid-mediated resistance.
Unit II
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Unit III
Molecular Pathogenesis (With Specific Examples)
Virulence, virulence factors, virulence- associated factors and virulence lifestyle factors, molecular genetics and gene regulation in virulence of pathogens, Vibrio Cholerae: Cholera toxin, coregulated pili, filamentous phage, survival E.coli pathogens: Enterotoxigenic E.coli (ETEC), labile and stable toxins, Entero- pathogenic E.coli (EPEC), type III secretion, cytoskeletal changes, intimate attachment; Enterohaemerrohogic E.coli (EHEC), mechanism of bloody diarrhoea and Hemolytic Uremic Syndrome, Enteroaggregative E.coli (EAEC). Shigella: Entry, macrophage apoptosis, induction of macropinocytosis, uptake by epithelial cells, intracellular spread, inflammatory response, tissue damage Plasmodium:Life cycle, erythrocyte stages, transport mechanism and processes to support the rapidly growing schizont, parasitiparous vacuoles, and knob protein transport, Antimalarials based on transport processes. Influenza virus: Intracellular stages, Neuraminidase and Haemagglutinin in entry, M1 and M2 proteins in assembly and disassembly, action of amantidine.
Unit IV
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Unit V
Modern Approaches To Control Pathogens
Classical approaches based on serotyping. Modern diagnosis based on highly conserved virulence factors, immuno& DNA-based techniques. New therapeutic strategies based on recent findings on molecular pathogenesis of a variety of pathogens, Vaccines – DNA, subunit and cocktail vaccines.
Course Outcome:
For the complete syllabus, results, class timetable, and many other features kindly download the iStudy App
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References:
- Iglewski B.H and Clark V.L Molecular basis of Bacterial Pathogenesis , Academic Press, 1990.
- Peter Williams, Julian Ketley& George Salmond, Methods in Microbiology: Bacterial Pathogenesis, Vol. 27, Academic Press, 1998.
- Recent reviews in Infect. Immun., Mol. Microbiol., Biochem. J., EMBO etc
- Nester, Anderson, Roberts, Pearsall, Nester, Microbiology: A Human Perspective, McGraw Hill, 3rd Edition, 2001.
- Eduardo A. Groisman, Principles of Bacterial Pathogenesis, Academic Press, 2001.
For detailed syllabus of all the other subjects of Pharmaceutical Technology 5th Sem, visit Pharma Tech 5th Sem subject syllabuses for 2019 regulation.
For all Pharmaceutical Technology results, visit Anna University Pharma Tech all semester results direct link.