Physical Pharmaceutics detail syllabus for Pharmacy (Pharma), 2017 regulation is taken from Anna University official website and presented for students of Anna University. The details of the course are: course code (PY8302), Category (PC), Contact Periods/week (3), Teaching hours/week (3), Practical Hours/week (0). The total course credits are given in combined syllabus.
For all other pharma 3rd sem syllabus for b.tech 2017 regulation anna univ you can visit Pharma 3rd Sem syllabus for B.Tech 2017 regulation Anna Univ Subjects. The detail syllabus for physical pharmaceutics is as follows.”
Course Objective:
- To acquire the fundamental principles and concepts involved in pharmaceutical powders, liquid flow, dispersions, drug diffusion, dissolution, complexation and protein binding.
- To provide the knowledge about kinetics and drug stability
Unit I
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Unit II
Surface and Interfacial Phenomenon, Viscosity and Rheology
Liquid interface, surface and interfacial tension, surface free energy, measurement of surface and interfacial tensions, free energy, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB classification, solubilization, detergency, adsorption at solid interface, solid gas and solid-liquid interface, complex films, electrical properties of interface. Newtonian system, Law of flow, kinematic viscosity, effect of temperature on viscosity, non-Newtonian systems, plastic, pseudoplastic, dilatant, thixotropy, thixotropy in formulation, determination of viscosity: capillary, falling ball, rotational viscometers.
Unit III
Dispersion Systems
Colloidal dispersions: Definition, types, properties of colloids, protective colloids, applications of colloids in pharmacy. Suspensions and Emulsions: Interfacial properties of suspended particles, settling in suspension, theory of sedimentation, effect of Brownian movement, sedimentation of flocculated particles, sedimentation parameters, wetting of particles, controlled flocculation, flocculation in structured vehicle, rheological considerations, emulsions; types, theories, physical stability.
Unit IV
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Unit V
Kinetics and Drug Stability
General considerations and concepts of drug reaction kinetics; zero order, first order and pseudo first order, half-life determination, Influence of temperature, light, catalytic species, solvent and other factors, Stabilization of drugs, Accelerated stability study, expiration dating.
Course Outcome:
- To know the fundamental properties of pharmaceutical solids
- To understand the surface, interfacial phenomena and the rheology of liquids
- Ability to understand the principles, characters and applications of pharmaceutical dispersions.
- To acquire the knowledge about drug diffusion, dissolution, complexation and protein binding.
- To be familiar with the degradation pathways, stabilization of drugs and their expiry date calculation.
Text Books:
- Manavalan, R. and Ramasamy. C. Physical Pharmaceutics 2nd Ed., Vignesh Publishers, 2015.
- C.V.S. Subrahmanyam, Text book of physical pharmaceutics, 3rdEdn., Vallabhprakashan, 2015.
- Hadkar. U. B., Physical Pharmacy, NiraliPrakashan; 12th edition, 2017.
References:
- Alfred N. Martin, Patrick J. Sinko, Martins Physical Pharmacy and Pharmaceutical Sciences: Physical Chemical and Biopharmaceutical Principles in the Pharmaceutical Sciences, sixth edition, Lippincott Williams and Wilkins, 2011.
- David B. Troy, Paul Beringer, Remington: The science and practice of pharmacy, 21st Edition, Lippincott Williams and Wilkins, 2006
- Humphrey Moynihan and Abinacrean Physicochemical Basis of Pharmaceuticals Oxford University Press, 2009.
For detail syllabus of all other subjects of B.Tech Pharma, 2017 regulation do visit Pharma 3rd Sem syllabus for 2017 Regulation.
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