Molecular Biology and Genetic Engineering detail syllabus for Pharmacy (Pharma), 2017 regulation is taken from Anna University official website and presented for students of Anna University. The details of the course are: course code (PY8404), Category (PC), Contact Periods/week (4), Teaching hours/week (4), Practical Hours/week (0). The total course credits are given in combined syllabus.
For all other pharma 4th sem syllabus for b.tech 2017 regulation anna univ you can visit Pharma 4th Sem syllabus for B.Tech 2017 regulation Anna Univ Subjects. The detail syllabus for molecular biology and genetic engineering is as follows.”
Course Objective:
- To expose students to application of recombinant DNA technology in biotechnological research.
- To train students in strategizing research methodologies employing cloning, construction of DNA libraries
- To illustrate creative use of modern tools and techniques for manipulation and analysis of genomic sequences.
Unit I
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Unit II
Transcription and Translation
Structure and function of mRNA, rRNA and tRNA. RNA synthesis: Initiation, elongation and termination of RNA synthesis, Translation: Introduction to Genetic code: Elucidation of genetic code, Codon degeneracy, Wobble hypothesis and its importance, Steps in translation: Initiation, Elongation and termination of protein synthesis. Inhibitors of protein synthesis. Post-translational modifications and its importance. Organization of genes in prokaryotic and eukaryotic chromosomes.
Unit III
Recombinant Dna Technology
Manipulation of DNA – Restriction and Modification enzymes. Characteristics of cloning and expression vectors based on plasmid and bacteriophage, Vectors for yeast, insect and mammalian systems, Prokaryotic and eukaryotic expression host systems, Introduction of recombinant DNA in to host: Insulin, Interferons, Erythropoietin, DNA libraries: Construction of genomic and cDNA libraries.
Unit IV
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Unit V
Genome Analysis and Genomics
Gene therapy and Transgenic technology, Introduction to Functional genomics, Microarrays, Serial Analysis of Gene expression (SAGE), Web resources for Genomics, Regulation of Eukaryotic Gene Expression by Small RNAs (RNA Interference, RNAi).
Course Outcome:
By the end of this course, students will be able to
- Describe the basic structure of nucleic acids, identify the principles of DNA replication, transcription and translation of proteins
- To produce the commercially important recombinant proteins
- Understand about gene expression and genome sequencing techniques
Text Books:
- David Friedfeld Molecular Biology. Narosa Publications, 1999.
- Primrose SB and R. Twyman Principles of Gene Manipulation and Genomic Blackwell Science Publications, 2006.
- Principles of Genome Analysis and Genomics by S.B. Primrose and R.M. Twyman, Third Edition (Blackwell Publishing), 2003.
References:
- Tropp, Burton. Molecular Biology: Genes to Proteins. 3rd Edition. Jones andBartlett, 2008.
- Ansubel FM, Brent R, Kingston RE, Moore DD, Current Protocols in Molecular BiologyGreene Publishing Associates, NY, 1998
- Genomes 3 by T.A.Brown, Third Edition (Garland Science Publishing), 2007.
For detail syllabus of all other subjects of B.Tech Pharma, 2017 regulation do visit Pharma 4th Sem syllabus for 2017 Regulation.
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