Bioseparation and Downstream Processing detailed syllabus for Chemical Engineering (CE) for 2021 regulation curriculum has been taken from the Anna Universities official website and presented for the CE students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Chemical Engineering 5th Sem scheme and its subjects, do visit CE 5th Sem 2021 regulation scheme. For Professional Elective-III scheme and its subjects refer to CE Professional Elective-III syllabus scheme. The detailed syllabus of bioseparation and downstream processing is as follows.
Course Objectives:
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Unit I
INTRODUCTION 9
Introduction to By-products and Bioseparation: Range and characteristics of bio products, Characteristics of Fermentation Broth, Selection of unit operation with due consideration of the physical, chemical and biochemical aspects of biomolecules. Stages of Downstream Processing
Unit II
CENTRIFUGATION AND FILTRATION 9
Primary Separation: Removal of insoluble and Biomass (and particulate debris) separation techniques, Flocculation and sedimentation, Centrifugation-Ultracentrifugation, Gradient centrifugation, Filtration: Theory of Filtration, Pre-treatment of Fermentation Broth, Filter Media and Equipment, Conventional and Cross-flow Filtration, Continuous Filtration, Filter cake resistance, specific cake resistance, Washing and dewatering of filter cakes
Unit III
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Unit IV
EXTRACTION 9
Liquid-Liquid Separation Process: Single Stage Operation, Equipments for liquid-liquid extraction. Types of extraction processes: Reactive extraction, Aqueous two-phase systems, Reverse micellar extraction, solid-liquid extraction, Supercritical fluid Extraction. Different types of extractors and designing of extractors. Distillation: Simple, Steam and Equilibrium distillation, Fractionation, Mccabe Thiele method, azotropes,
Unit V
CHROMATOGRAPHY AND MEMBRANE SEPARATION 9
Theory of chromatography, Shape and yield of a chromatographic peak, Binary chromatography, Hydrodynamic chromatography. Membrane-based bioseparation – Classification of membrane processes, Ultrafiltration, Microfiltration, Dialysis, Liquid membrane processes, Membrane chromatography, Electrophoresis, Affinity ultrafiltration, Field-flow fractionation
Course Outcomes:
On completion of the course, the students will be able to
- understand the basic concept of bioseparation processes
- acquire knowledge on theory, design, and application of bioprocessing
- to understand the basic concepts absorption and their problems in bioprocessing
- gather knowledge on extraction of bioproducts using different methods
- acquire knowledge on chromatography techniques and their analysis, membrane separation process
Text Books:
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Reference Books:
- P.A. Belter, E.L. Cussler and Wei-Shou Hu., Bioseparations-Downstream Processing for Biotechnology, Wiley Interscience Publication, 1988.
- R. K. Scopes, Berlin, Protein Purification: Principles and Practice, Springer, 1982. ScopesAk, Protein Purification, IRL Press, 1993
- Biotechnology: Bioprocessing, Rhem and Reed, Vol. 3, 1993
- Separation and purification techniques in biotechnology, Fredreich Dechow, 1989
- T. Schepler et al, Biotreatment, Downstream Processing and Modeling (Advances in Biochemical Engineering /Biotechnology, Vol 56) by Springer Verlag
For detailed syllabus of all the other subjects of Chemical Engineering 5th Sem, visit CE 5th Sem subject syllabuses for 2021 regulation.
For all Chemical Engineering results, visit Anna University CE all semester results direct link.