Bioorganic Chemistry detail syllabus for Biotechnology (Biotech), 2017 regulation is taken from Anna University official website and presented for students of Anna University. The details of the course are: course code (BT8304), Category (PC), Contact Periods/week (3), Teaching hours/week (3), Practical Hours/week (0). The total course credits are given in combined syllabus.
For all other biotech 3rd sem syllabus for b.tech 2017 regulation anna univ you can visit Biotech 3rd Sem syllabus for B.Tech 2017 regulation Anna Univ Subjects. The detail syllabus for bioorganic chemistry is as follows.”
Course Objective:
To enable the students
- To know in detail about the elements of atom, charges and their bonding rule.
- To understand the various kinetic properties and types of reaction mechanisms
- To understand the possible bio-organic reactions involved in biosynthesis
Unit I
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Unit II
Mechanisms of Substitution and Addition Reactions
SN1 and SN2 reactions on tetrahedral carbon- nucleophiles- mechanism steric effects -nucleophilic addition on Acetals and ketals -Aldehyde and ketone groups – reactions of carbonyl group with amines- acid catalyzed ester hydrolysis – Saponification of an ester- hydrolysis of amides. Ester enolates – claisen .condensation – Michael condensation.
Unit III
Kinetics and Mechanism
Kinetic method – Rate law and mechanism – Transition states- Intermediates – Trapping of intermediates – Microscopic reversibility – Kinetic and thermodynamic reversibility – Isotopes for detecting intermediates. Primary and secondary isotopes – the Arrhenius equation Eyring equation – AG, AS, AH, Thermodynamics of coupled reactions.
Unit IV
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Unit V
Bioorganic Reactions
Timing of Bond formation and fission – Acyl group transfer – C-C bond formation and fission -Catalysis of proton transfer reactions – Transfer of hydride ion – Alkyl group. Transfer – Terpene biosynthesis – Merrifield state peptide synthesis – Sanger method for peptide and DNA sequencing
Course Outcome:
- On completion of this course, the students will learn the basics principles of chemical Bonding, Stereochemistry of Bio-organic molecules and their kinetics, mechanisms of reactions and catalysis.
Text Books:
- Carey, Francis A. Organic Chemistry. VIIth Edition, Tata MCGraw Hill, 2009.
- Page, M.I. and Andrew Williams Organic and Bio-organic Mechanisms. Pearson, 2010.
References:
- Dugas, Hermann Bioorganic Chemistry: A Chemical Approach to Enzyme Action 3rd Edition, Springer, 2003.
For detail syllabus of all other subjects of B.Tech Biotech, 2017 regulation do visit Biotech 3rd Sem syllabus for 2017 Regulation.
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