Vaccine Technology detailed syllabus for Biotechnology & Biochemical Engineering (BBE) for 2021 regulation curriculum has been taken from the Anna Universities official website and presented for the BBE students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Biotechnology & Biochemical Engineering 5th Sem scheme and its subjects, do visit BBE 5th Sem 2021 regulation scheme. For Professional Elective-III scheme and its subjects refer to BBE Professional Elective-III syllabus scheme. The detailed syllabus of vaccine technology is as follows.
Course Objectives:
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Unit I
INTRODUCTION TO VACCINATION 9
Vaccination: Introduction, history and principles of vaccine development. Conventional and modern strategies for vaccine improvement. Immunization strategies: Active and Passive. Epidemiology and pathophysiology of vaccine preventable diseases with special emphasis on Diphtheria, Tetanus, Hepatitis, Human papillomavirus.
Unit II
CLASSIFICATION OF VACCINES AND ITS PRODUCTION 9
Types of vaccines: Live, attenuated, subunit, killed vaccines, Recombinant peptide vaccines, recombinant live vector vaccines, conjugate vaccines, toxoid vaccines, Naked DNA vaccines, cellbased vaccines, edible vaccines. Reverse vaccinology. Adjuvants: history, classification, mechanisms. Factors affecting adjuvants selection and production.
Unit III
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Unit IV
VACCINE DESIGN AND DEVELOPMENT 9
Fundamental research to rational vaccine design. Antigen identification and delivery, T-Cell expression cloning for identification of vaccine targets for intracellular pathogens, Fundamentals of Immune recognition, implications for manipulating the T-Cell repertoire, Targeting Dendritic cells; a rational approach for Vaccine development, Cellular basis of T- Cell memory, Rational design of new vectors, CpG adjuvant activity, Transcutaneous immunization.
Unit V
COMMERCIAL PRODUCTION AND REGULATORY GUIDELINES 9
Quality control and regulations in vaccine research, In-vitro experimental validations for predictions of vaccines by software, Animal testing, Rational design to clinical trials, Large scale production, Commercialization, ethics. Overview of national and international regulatory requirements/ guidance for production of vaccines, quality control and implementation of good clinical practices. Overview of currently approved methods and alternative methods under development. Storage and handling, assessment of vaccine safety.
Course Outcomes:
The students will be able to
- Describe the role of immune cells and their mechanism and concept of vaccination.
- Categorize the different types of vaccines available for diseases.
- Understand the modern strategies and routes of immunization.
- Apply the concept of vaccine technology for development of vaccines
- Evaluate various delivery methods suitable for vaccines.
- Relate the quality control and regulatory guidelines involved in vaccine production.
Text Books:
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Reference Books:
- Myrone M. Levine , Myron M. Levine, Gordon Dougan , Michael F. Good , Margaret A. Liu , Gary J. Nabel , James P. Nataro, RinoRappuoli., New Generation Vaccines. Fourth Edition, 2016
- Stanley Plotkin Walter Orenstein Paul Offit, Vaccines, 6th Edition, 2012
For detailed syllabus of all the other subjects of Biotechnology & Biochemical Engineering 5th Sem, visit BBE 5th Sem subject syllabuses for 2021 regulation.
For all Biotechnology & Biochemical Engineering results, visit Anna University BBE all semester results direct link.