Pharmaceutical Biotechnology detailed syllabus for Biotechnology & Biochemical Engineering (BBE) for 2021 regulation curriculum has been taken from the Anna Universities official website and presented for the BBE students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Biotechnology & Biochemical Engineering 5th Sem scheme and its subjects, do visit BBE 5th Sem 2021 regulation scheme. For Professional Elective-III scheme and its subjects refer to BBE Professional Elective-III syllabus scheme. The detailed syllabus of pharmaceutical biotechnology is as follows.
Course Objectives:
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Unit I
BIOTECHNOLOGY WITH REFERENCE TO PHARMACEUTICAL SCIENCES 9
Introduction to Biotechnology with reference to Pharmaceutical Sciences, Biosensors- Working and applications of biosensors in Pharmaceutical Industries. Brief introduction to Protein Engineering. Use of microbes in industry. Production of Enzymes- General consideration – Amylase, Catalase, Peroxidase, Lipase, Protease, Penicillin’s.
Unit II
GENETIC ENGINEERING 9
Basic principles of genetic engineering. Study of cloning vectors, restriction endonucleases and DNA ligase. Recombinant DNA technology. Application of genetic engineering in medicine. Application of rDNA technology and genetic engineering in the products: Interferon b) Vaccines-hepatitis- B c) Hormones- Insulin. Nanodrops, Gene expression analysis.
Unit III
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Unit IV
IMMUNOLOGICAL TECHNIQUES AND ANALYSIS 9
Immunoblotting techniques- ELISA, Western blotting, Southern blotting. Genetic organization of Eukaryotes and Prokaryotes. Microbial genetics including transformation, transduction, conjugation,plasmids and transposons. Introduction to Microbial biotransformation and applications.
Unit V
GENE MUTATION AND FERMENTATION 9
Mutation. Types of mutation/mutants. Fermentation methods and general requirements, study of media, equipments, sterilization methods, aeration process, stirring. Large scale production fermenter design and its various controls. Study of the production of – penicillin, citric acid, Vitamin B12, Glutamic acid, Griseofulvin.
Course Outcomes:
The students will be able to
- Will be familiar with resources, of DNA based vaccine delivery systems.
- Will be able to analyze Screening, isolation, characterization and scale-up of microbial products (enzymes, antibiotics and other secondary metabolites) from microorganisms of commercial interest and its pharmacological evaluation.
- Will be able to Microbial synthesis of nanoparticles: Biosynthesis, isolation and characterization.
- Will develop skills in molecular signalling pathways in pathogenesis and therapy.
- Will be familiar in Immunoproliferators: Isolation, characterization and evaluation of cytokine like molecules from microbial source.
- Will be familiar with the Peptide therapeutics: Design, evaluation and formulation of peptides for therapeutics.
Text Books:
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Reference Books:
- Biotechnology of antibiotics and other bioactive microbial metabolites : Gianeario Lancini and Rolando Lorenzetti.
- Pharmaceutical Biotechnology by Daan J. A. Crommelin, et al
- Goodman and Gilman’s The Pharmacological Basis of Therapeutics Book by J.Hardman, Lee Limbird and A.G. Gilman.
- “Principles of Pharmacology by D. Golan, A. Tashjian, E. Armstrong, J.Galanter, A.W.Armstrong, R. Arnaout and H.Rose. 2005, Lippincott Williams and Wilkins.
For detailed syllabus of all the other subjects of Biotechnology & Biochemical Engineering 5th Sem, visit BBE 5th Sem subject syllabuses for 2021 regulation.
For all Biotechnology & Biochemical Engineering results, visit Anna University BBE all semester results direct link.