Molecular Medicine and Diagnostics detailed syllabus for Biotechnology & Biochemical Engineering (BBE) for 2021 regulation curriculum has been taken from the Anna Universities official website and presented for the BBE students. For course code, course name, number of credits for a course and other scheme related information, do visit full semester subjects post given below.
For Biotechnology & Biochemical Engineering 5th Sem scheme and its subjects, do visit BBE 5th Sem 2021 regulation scheme. For Professional Elective-III scheme and its subjects refer to BBE Professional Elective-III syllabus scheme. The detailed syllabus of molecular medicine and diagnostics is as follows.
Course Objectives:
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Unit I
INTRODUCTION TO MOLECULAR MEDICINE, NANOMEDICINE 9
Extracellular and intracellular signaling systems. Methods of DNA analysis and gene technology. Nanomedicine – Overview. Identification of genes and variants in the genome and gene mapping.
Unit II
MOLECULAR AND MEDICAL MICROBIOLOGY 9
Molecular methods for detection and characterization of microorganisms, Primer and probe design. Databases – Molecular genetic assays, genotypic assays for molecular epidemiology.
Unit III
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Unit IV
INTRODUCTION TO MOLECULAR DIAGNOSTICS 9
Introduction and History of diagnostics, Diseases- infectious, physiological and metabolic errors, genetic basis of diseases, inherited diseases. Infection – mode of transmission in infections, factors predisposing to microbial pathogenicity, types of infectious diseases- bacterial, viral, fungal, protozoans and other parasites. • Philosophy and general approach to clinical specimens, Sample collection- method of collection, transport and processing of samples, Interpretation of results, Normal microbial flora of the human body, Host -Parasite relationships.
Unit V
DIAGNOSTIC TESTS AND DISEASES 9
Duchenne muscular Dystrophy (Creatine phosphokinase-CPK), Amino acid deficiency – PKU (phenylketonuria) — Inborn error, G6PD deficiency syndrome (G6PD), Sickle cell anemia, PCR diagnosis of Tuberculosis, Prenatal screening of Cystic Fibrosis. Endocrine disorders related to thyroid and reproduction (TSH, T3, T4, Estradiol, Testosterone, LH, FSH). Pyrosequencing. Lab on a Chip. Personalized Medicine – Pharmacogenomics.
Course Outcomes:
The students will be able to
- Recognize molecular mechanisms in development of disease
- Predict the use of molecular genetic methods in the detection, identification and quantification of different microorganisms.
- Apply the principles of molecular diagnostics and advantages/limitations of its applications
- Develop technological integration of chemistry, physics and molecular biology for use in bioanalysis relevant for biomedical research and diagnostics.
- Design advanced study in the theoretical and practical aspects of the genetic basis and diagnosis of disease from both human and pathogen perspectives.
- Appraise the knowledge of molecular testing to the most commonly performed applications in the clinical laboratory such as: nucleic acid extraction, resolution and detection, analysis and characterization of nucleic acids and proteins, nucleic acid amplification and DNA sequencing
Text Books:
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Reference Books:
- Principles of Biochemistry (Lehinger) (5th edition), MM Cox and DL Nelson, CBS Publishers, 2013.
- Molecular Cell Biology: Darnell J, Lodish H and Baltimore D, 5th Edition, 2003.
- Principles of Immunology and Immunodiagnostics: Ralph Michael Aloisi. Lippincott Williams and Wilkins, 1988.
- Genomes (3rd edition) TA Brown, Garland Science Publishing, 2006
For detailed syllabus of all the other subjects of Biotechnology & Biochemical Engineering 5th Sem, visit BBE 5th Sem subject syllabuses for 2021 regulation.
For all Biotechnology & Biochemical Engineering results, visit Anna University BBE all semester results direct link.