Molecular Pathogenesis of Infections Disease for Biotechnologists Syllabus for B.Tech Sixth sem is covered here. This gives the details about credits, number of hours and other details along with reference books for the course.
The detailed syllabus for Molecular Pathogenesis of Infections Disease B.Tech 2016-2017 (R13) sixthsem is as follows
OBJECTIVES: To enable the students
- To understand about the microbial toxins and modern molecular pathogenesis
- To know about the host pathogen interaction and identifying virulence factors
- To control pathogens by modern approaches.
UNIT I : OVERVIEW [5 Hours]
Historical perspective – discovery of microscope, Louis Pasteur’s contributions, Robert Koch’s postulates, early discoveries of microbial toxins, toxic assays, vaccines, antibiotics and birth of molecular genetics and modern molecular pathogenesis studies, Various pathogen types and modes of entry.
UNIT II : HOST-DEFENSE AGAINST PATHOGENS AND PATHOGENIC
STRATEGIES [8 Hours]
Attributes & components of microbial pathogenesis, Host defense: skin, mucosa, cilia, secretions, physical movements, limitation of free iron, antimicrobial compounds, mechanism of killing by humoral and cellular defense mechanisms, complements, inflammation process, general disease symptoms, Pathogenic adaptations to overcome the above defenses.
UNIT III : MOLECULAR PATHOGENESIS (WITH SPECIFIC EXAMPLES) [16 Hours]
Virulence, virulence factors, virulence-associated factors and virulence lifestyle factors, molecular genetics and gene regulation in virulence of pathogens, Vibrio Cholerae: Cholera toxin, co-regulated pili, filamentous phage, survival E.coli pathogens: Enterotoxigenic E.coli (ETEC), labile & stable toxins, Entero- pathogenic E.coli (EPEC), type III secretion, cytoskeletal changes, intimate attachment; Enterohaemerrohogic E.coli (EHEC), mechanism of bloody diarrhoea and Hemolytic Uremic Syndrome, Enteroaggregative E.coli (EAEC). Shigella: Entry, macrophage apoptosis, induction of macropinocytosis, uptake by epithelial cells, intracellular spread, inflammatory response, tissue damage Plasmodium: Life cycle, erythrocyte stages, transport mechanism and processes to support the rapidly growing schizont, parasitiparous vacuoles, and knob protein transport, Antimalarials based on transport processes. Influenza virus: Intracellular stages, Neuraminidase & Haemagglutinin in entry, M1 & M2 proteins in assembly and disassembly, action of amantidine.
TOTAL : 45 PERIODS
OUTCOMES: Upon completion of this course, the student will be able to
understand the
- Host pathogen interactions at the level of cellular and molecular networks.
- Diagnosis of diseases through the examination of molecules.
- Modern therapeutic strategies on various pathogens.
TEXTBOOKS:
- Iglewski B.H and Clark V.L “ Molecular basis of Bacterial Pathogenesis “, Academic Press, 1990.
- Eduardo A. Groisman, Principles of Bacterial Pathogenesis, Academic Press,
2001.
REFERENCES:
- Peter Williams, Julian Ketley & George Salmond, “Methods in Microbiology : Bacterial Pathogenesis, Vol. 27”, Academic Press, 1998.
- Recent reviews in Infect. Immun., Mol. Microbiol., Biochem. J., EMBO etc
- Nester, Anderson, Roberts, Pearsall, Nester, “Microbiology: A Human Perspective”, Mc Graw Hill, 3rd Edition, 2001.
- Brenda B. Wilson, Abigail A. Salyers, Dixie D. Witt, Malcolm E. Winkler, “Bacterial
Pathogenesis”, ASM press, 3rd Edition, 2011.
For all other B.Tech BT 6th sem syllabus go to Anna University B.Tech BIOTECHNOLOGY 6th Sem Course Structure for (R13) Batch. All details and yearly new syllabus will be updated here time to time. Subscribe, like us on facebook and follow us on google plus for all updates.
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