Pharmaceutical Organic Chemistry – II Detailed Syllabus for B.Tech first year second sem is covered here. This gives the details about credits, number of hours and other details along with reference books for the course.
The detailed syllabus for Pharmaceutical Organic Chemistry – II B.Tech 2016-2017 (R16) first year second sem is as follows.
B.Tech. I Year II Sem. L T/P/D C
Course Code: BS202 4 /1/0 4
Course Objectives:
The organic compounds are classified based on their functional groups and character. The basic principles and mechanisms of different types of organic reactions are explained in an elaborative manner.
Course Outcome:
The detailed study on the mechanisms involved in various reactions would help the students to understand the synthesis of higher organic compounds which would be dealt in future classes.
UNIT – I Carbonyl Compounds: Nomenclature, two important methods of preparation, polarity of carbonyl group, relative reactivities of carbonyl compounds, nucleophilic addition and addition-elimination reactions, oxidation-reduction reactions, aldol condensation, Cannizzaro reaction, benzoin condensation, Perkins reactions, Reformatsky reaction, Oppenauer oxidation.
UNIT – II a. Ethers: Nomenclature, Williamson’s synthesis, action of hydro iodic acid on ethers (Ziesel’s method). b. Phenols: Nomenclature, general methods of preparation, physical properties, acidity of phenols, stability of phenoxide ion, reactions of phenols, Kolbe-schmidt reaction stability of conjugated dienes, and Fries rearrangement, Reamer-Tiemann Reaction.
UNIT – III a. Carboxylic acids and their derivatives: Carboxylic acids: Nomenclature, intermolecular association, stability of carboxylate anion, two important methods of preparation, decarboxylation, functional groups reactions, reduction of carboxylic acids. a note on dicarboxylic acids. b. Acid derivatives: (acid chlorides, anhydrides, esters and amides). Nomenclature, reactions like hydrolysis, reduction of esters and amides, Hofmann’s degradation of amides.Brief account of preparation and properties of malonic and acetoacetic esters, their importance in organic syntheses.
TEXT BOOKS:
- T. R. Morrison and R. N. Boyd, Organic chemistry, prentice hall of India private Limited, New Delhi.
- I.L. Finar Vol.I. & Vol. II., the Fundamentals Principles of Organic Chemistry, ELBS/Longman.
- Ball & Ball, Advanced pharmaceutical organic chemistry.
REFERENCES:
- Jerry March, Advanced Organic Chemistry
- Bruce, Organic chemistry
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