Protein Engineering and in Silico Drug Design detail syllabus for Biotechnology (BT), 2017 scheme is taken from VTU official website and presented for VTU students. The course code (17BT831), and for exam duration, Teaching Hr/week, Practical Hr/week, Total Marks, internal marks, theory marks, duration and credits do visit complete sem subjects post given below.
For all other bt 8th sem syllabus for be 2017 scheme vtu you can visit BT 8th Sem syllabus for BE 2017 Scheme VTU Subjects. For all other Professional Elective-5 subjects do refer to Professional Elective-5. The detail syllabus for protein engineering and in silico drug design is as follows.
Course Objectives:
The course imparts advanced knowledge on proteins through a detailed study of protein Structure, its characteristic properties and significance in biological systems.
Module 1
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Module 2
CHARACTERIZATION & APPLICATIONS OF PROTEIN ENGINEERING: NMR spectroscopy, crystallography, spectroscopic and calorimetric methods. Design of polymeric biomaterials, nicotinic acetylcholine receptors as a model for a super family of ligand – gated ion channel proteins.
Module 3
MOLECULAR MODELING: Constructing an Initial Model, Refining the Model, Manipulating the Model, Visualization. Structure Generation or Retrieval, Structure Visualization, Conformation Generation, Deriving Bioactive Conformations, Molecule Superposition and Alignment, Deriving the Pharmacophoric Pattern, Receptor Mapping, Estimating Biological Activities, Calculation of Molecular Properties, Examples of Small Molecular Modeling Work, Nicotinic Ligands.
Module 4
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Module 5
DOCKING METHODS:
Program GREEN Grid: Three – Dimensional Description of Binding Site Environment and Energy Calculation, Automatic Docking Method, Three-Dimensional Database Search Approaches, Automated Structure Construction Methods, Structure Construction Methods with known Three-Dimensional Structure of the Receptor, Structure Construction in the case of Unknown Receptor Structure. Points for Consideration in Structure Construction Methods, Handling of X-Ray Structures of Proteins, Future Perspectives. Other web based programs available for molecular modeling, molecular docking and energy minimization techniques -Scope and limitations, interpretation of results.
Course Outcomes:
After studying this course, students will be able to:
- Outline the structural properties of proteins and their determination methods
- Understand protein design principles and database analysis
- Design Proteins in silico.
Reference Books:
- Bioinformatics Methods & Applications: Genomics, Proteomics & Drug Discovery, S C Rastogi,N Mendiratta & P Rastogi, PHI.
- A.R Leach, Molecular Modeling Principles and Applications, Longman, 1996.
- J.M. Haile , Molecular Dynamics Simulation Elementary methods, , John Wiley and Sons,1997
Text Books:
- Protein engineering and design by Paul R. Carey, academic press, 1996, 361 pages.
- Protein Structure by Creighton, Oxford University Press.
- Introduction of protein structure by Branden C. and Tooze R., Garland.
- The molecular modeling perspective in drug design by N Claude Cohen, Academic Press
For detail syllabus of all other subjects of BE Bt, 2017 regulation do visit Biotech 8th Sem syllabus for 2017 Regulation.
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