Genomics & Proteomics detail syllabus for Biotechnology (Bt), 2017 scheme is taken from VTU official website and presented for VTU students. The course code (17BT72), and for exam duration, Teaching Hr/week, Practical Hr/week, Total Marks, internal marks, theory marks, duration and credits do visit complete sem subjects post given below.
For all other bt 7th sem syllabus for be 2017 scheme vtu you can visit BT 7th Sem syllabus for BE 2017 Scheme VTU Subjects. The detail syllabus for genomics & proteomics is as follows.
Course Objectives:
This course will enable students
- To inculcate interdisciplinary approach of learning.
- To comprehend applications of basic aspects of biotechnology
- To impart knowledge on application of software tools for biological studies
Module 1
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Module 2
GENOMICS: Inheritance pattern in eukaryotes, Mutations, Gene variation and Single Nucleotide Polymorphisms (SNPs), Expressed sequenced tags (ESTs), Gene-disease association, diagnostic genes and drug targets, genotyping tools – DNA Chips, diagnostic assays, diagnostic services; comparative genomics. Functional genomic studies with model systems such as Drosophila, Yeast or C. elegans.
Module 3
GENOME MANAGEMENT : Cell differentiation and gene regulation. C-Values of genomes. General architecture of prokaryotic and eukaryotic genome. Organization of eukaryotic genome within the nucleus, chloroplast and mitochondria. Regulation of transcription, transcription factors and the coordination of gene expression, translation and post-translational modification in eukaryotes. Interference RNA, RNA silencing, SiRNA: Applications in Functional genomics, Medicine and Gene Knockdown.
Module 4
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Module 5
PROTEOMICS :
Introduction to proteins, Large scale preparation of proteins and peptides, Merrifield Synthesis of peptides, use of peptides as probes. Proteomics databases, proteins as drugs; two hybrid interaction screens. Mass-spec based analysis of protein expression and post-translational modifications. “Protein Chip” – interactions and detection techniques. Methods of measurement of mRNA expression, Two dimensional PAGE for proteome analysis, Automation in proteomics, Applications of proteome analysis to drug development and toxicology, Phage antibodies as tools for proteomics.
Course Outcomes:
After studying this course, students will be able to:
- Define structural, comparative and functional genomics and proteomics and its uses in various research fields.
- Explain the various techniques involved in the extraction and utilization of enzymes in biotransformation
Reference Books:
- Biocomputing Informatics and the Genome Projects by Smith D.W., Academic 1993.
- Genes VIII by Benjamin Lewis. Oxford University & Cell Press, 2007.
- Bioinformatics – Methods And Applications: Genomics, Proteomics And Drug Disc By S C Rastogi, N Mendiratta & P Rastogi, Phi, 2006
Text Books:
- Introduction to Genomics by Arthur M Lesk, Oxford University Press, 2007.
- Plant Genome Analysis. Edited by Peter M Gresshoff, CRC Press.
- Genetic Analysis – Principles, Scope and Objectives by JRS Finchman, Blackwell Sc 1994.
- Discovering Genomics, Proteomics & Bioinformatics by A M Campbell & L J Heyer, Pearson Education, 2007
- Protein Arrays, Biochips and Proteomics by J S Albala & I Humprey-Smith, CRC Press, 2003
- Genomics & Proteomics by Sabesan, Ane Books, 2007
- Purifying Proteins for Proteomics by Richard J Simpson, IK International, 2004
- Proteins and Proteomics by Richard J Simpson, IK International, 2003
For detail syllabus of all other subjects of BE Bt, 2017 scheme do visit Biotech 7th Sem syllabus for 2017 scheme.
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