Fermentation Technology BT 7th Sem Syllabus for VTU BE 2017 Scheme

Fermentation Technology detail syllabus for Biotechnology (Bt), 2017 scheme is taken from VTU official website and presented for VTU students. The course code (17BT71), and for exam duration, Teaching Hr/week, Practical Hr/week, Total Marks, internal marks, theory marks, duration and credits do visit complete sem subjects post given below.

For all other bt 7th sem syllabus for be 2017 scheme vtu you can visit BT 7th Sem syllabus for BE 2017 Scheme VTU Subjects. The detail syllabus for fermentation technology is as follows.

Course Objectives:

This course will enable students to

• Define the fundamentals of downstream processing for biochemical product recovery.
• Understand the concepts of secondary metabolite production.
• Assess the impact of change in unit’s operations and the impact on the process.
• Examine traditional unit operations, as well as new concepts and emerging technology that is likely to benefit biochemical product recovery in the future.
• Analyze both analytical and process validation issues that are critical to successful manufacturing, focusing on large-scale, high-purity protein production.
• Model biochemical product recovery, including small molecule purification.
• Examine strategies for biochemical process synthesis

Module 1

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Module 2

PRODUCTION OF SECONDARY METABOLITES & ANTIBIOTIC TECHNOLOGY: Secondary metabolite production-strategies for optimizing product yield, culture conditions, selection of high yielding lines, elicitation, immobilization of cultures, hairy root culture and biotransformation. Factors affecting secondary metabolites, industrial application of secondary metabolites. Hybridoma technology for monoclonal antibody production. Applications of custom made monoclonal antibodies. Bioreactors considerations for animal cell cultures – Production of Monoclonal antibodies and therapeutic proteins.

Module 3

IMPORTANCE OF DOWNSTREAM PROCESSING AND PRIMARY SEPARATION TECHNIQUES: Role and importance of downstream processing in biotechnological processes. Problems and
requirements of byproduct purification. Economics of downstream processing in Biotechnology.Cost cutting strategies, Characteristics of biological mixtures,
Cell disruption methods for intracellular products, removal of insolubles, biomass (and particulate debris) separation techniques; flocculation and sedimentation, Centrifugation (ultra and differential) , filtration methods and Principle and Applications of Electrophoresis – their types.

Module 4

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Module 5

PRODUT RECOVERY – TRADITIONAL AND ADSORPTIVE SEPARATION:
Chromatographic separation processes, Electrophoretic separations, hybrid separation technologies, Dialysis; Crystallization. Partition chromatography – Single dimensional (Both Ascending and Descending) and two dimensional chromatography – Thin layer chromatography, Gas liquid Chromatography,
Adsorption column chromatography. Ion Exchange Chromatography: Cation Exchange and Anion Exchange chromatography. Gel Filtration Chromatography, Hydrophobic interaction chromatography, Affinity Chromatography, High Performance liquid chromatography (HPLC) -analytical and preparative.

Course Outcomes:

After studying this course, students will be able to:

• Describe the factors affecting secondary metabolite production and its industrial importance.
• Describe the basic requirements of downstream processing for biochemical product recovery.
• Identify and summarize the effect of change in unit’s operations and its impact on the process.
• Illustrate how emerging technologies would benefit the bio chemical product recovery and show the likely benefits it would have over the traditional operations.
• Analyzing both analytical and process validation issues that are critical to successful manufacturing.
• Outline the processes involving large-scale, high-purity protein production

Reference Books:

1. Rate controlled separations by Wankat P.C., Elsevier.
2. Animal cell culture Techniques by Ian Freshney, Wiley-Liss.
3. Animal Cell biotechnology by R.E. Spier and J.B. Griffiths, Academic press.
4. Bioprocess Engineering by Shule and Kargi, Prentice Hall.
5. Bioprocess Engineering – Kinetics, Mass Transport, Reactors and Gene Expression by Wolf
6. R. Vieth, Wiley – Interscience Publication.
7. Enzymes in Industry: Production and Applications : W. Gerhartz, VCH Publishers, New York.
8. Enzyme Technology by M.F. Chaplin and C. Bucke, Cambridge University Press.
9. Bioseparation Engineering by Ajay Kumar, IK Intl.Ltd

Text Books:

1. Principles of fermentation Technology by P.F. Stanbury and A. Whitaker, Pergamon Press.
2. Animal Cell Technology by Asok Mukhopadyay, IK Intl. Ltd.
3. Downstream Process Technology – A new horizon in Biotechnology by Nooralabetta Krishna Prasad, PHI Learning Private Limited.
4. Bioseparation – Downstream processing for biotechnology by Belter P.A., Cussier E. and Wei Shan Hu., Wiley Interscience Pub.
5. Separation Processes in Biotechnology by Asenjo J. et al., Marcel Dekker Publications.
6. Bioseparations by Belter P.A. and Cussier E., Wiley.
7. Product Recovery in Bioprocess Technology – BIOTOL Series,VCH.
8. Fermentation & Enzyme Technology by D.I.C. Wang et.al., Wiley Eastern.
9. Purifying Proteins for Proteomics by Richard J Simpson, IK International.
10. BIOSEPARATIONS: Science and Engineering by ROGER G HARRISON, Oxford Publications.

For detail syllabus of all other subjects of BE Bt, 2017 scheme do visit Biotech 7th Sem syllabus for 2017 scheme.

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