Advanced Medicinal Chemistry II Detailed Syllabus for Pharmaceutical Chemistry M.Pharm first year second sem is covered here. This gives the details about credits, number of hours and other details along with reference books for the course.
The detailed syllabus for Advanced Medicinal Chemistry II M.Pharm 2017-2018 (R17) first year second sem is as follows.
M.Pharm. I Year II Sem.
Course Objective: The course contents of Unit I and Unit II are mainly aimed at enzyme inhibitors for the treatment of different CNS and CVS diseases. Unit III contents are aimed to have advanced knowledge of the developments of antipsychotic agents. The remaining contents are aimed to design prodrugs, peptidomimetic agents and recombinant DNA products.
Course Outcome: The student would be in a position to involve in the development of different enzyme inhibitors, prodrugs and also equipped with different biotechnological techniques of recombinant DNA products.
UNIT I : Enzyme Inhibitors I: A detailed study of the following types of enzyme inhibitors, related drugs and their pharmaceutical significance:
- Prostaglandin Synthetase (Cycloxygenase & Lipoxygenase Inhibitors)
- Phosphodiesterase (PDE) Inhibitors
- Carbonic Anhydrase Inhibitors.
- B- Secretase.
UNIT II : Enzyme Inhibitors II:
- Angiotensin Converting Enzyme (ACE) Inhibitors
- Acetyl Cholinesterase (Ach E) Inhibitors.
- HMG-CoA inhibitors
- Protease inhibitors
UNIT III : Antipsychotic Agents: Role of Dopamine, Serotonin, Glutamate and their receptors. SAR and Pharmacokinetics of Ticyclic Neuroleptics, Butyrophenones and Benzamides. A brief account of non benzodiazepine agonist.
UNIT IV : Peptidmimetic agents & Prodrugs
- Physiological role of peptids, Endogenous peptide transmitters & function, cyclosporin and oxytocin
- Prodrugs belong to esters, Lactones, amides, hydrazides and azo compounds. Targetted prodrug, bioprecurror of prodrugs
UNIT V : Biotechnologically produced drugs: Biotechnology of Recombinant DNA, Process of Recombinant proteins, Immunogenicity of biotechnologically produced drugs. Recombinant drug products: Hormones, cytokinins, interferons, Interleukins, enzymes, vaccines and monoclonal antibody drugs.
RECOMMENDED BOOKS:
- Berger’s Medicinal Chemistry and Drug Design. 6th Edition
- Korolkovas Essentials of Medicinal Chemistry
- William O Foye Medicinal Chemistry
- Lednicer, Organic Chemistry of Drug Synthesis
- Ariens, Drug Design , Academic Press
- Purcell Strategies of Drug Design
- Corwin , Hansen Comprehensive Medicinal Chemistry
- Richard B. Silvermann, Org. Chemistry of Drug Design and drug Action
- Smith and Williams , Introduction to principles of Drug Design – Harwood Academy Press
- Gyorgy Keri & Istdan Toth Molecular Pathomechanism and New Trends in Drug Research, Taylor & Francis Pub
- Thomas Nogrady, Medicinal Chemistry. A biochemical Approach, Oxford Univ. Press.
For all other M.Pharm 1st Year 2nd Sem syllabus go to JNTUH Pharmaceutical Chemistry 1st Year 2nd Sem Course Structure for (R17) Batch.
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