Structural Biology BT 4th Sem Syllabus for VTU BE 2017 Scheme

Structural Biology detail syllabus for Biotechnology (Bt), 2017 scheme is taken from VTU official website and presented for VTU students. The course code (17BT45), and for exam duration, Teaching Hr/week, Practical Hr/week, Total Marks, internal marks, theory marks, duration and credits do visit complete sem subjects post given below.

For all other bt 4th sem syllabus for be 2017 scheme vtu you can visit BT 4th Sem syllabus for BE 2017 Scheme VTU Subjects. The detail syllabus for structural biology is as follows.

Course Objectives:

This course will enable students to

• Appreciate the importance of structure, scope and function of macromolecules.
• Understand the structure organization, work and function of macromolecules at molecular level.
• Know the various qualitative and quantitative physical methods available for structure elucidation.
• Learn the various interactions involved in macromolecular structure and their roles towards stability and function

Module 1

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Module 2

STRUCTURE OF NUCLEIC ACIDS AND BIOMEMBRANES: General characteristics of nucleic acid structures (A, T, G, C, U), forces and stabilizing geometries, glycosidic bond, rotational isomers. Stabilizing ordered forms of DNA (A, B and Z), base pairing types, base stacking, tertiary structure of DNA (Supercoiled DNA), Melting of the DNA double helix (Hyperchromicity), Interaction with small ions and small molecules. Ribose puckering and Tertiary structure of tRNA. Structure and conformational properties of cell membranes, Singer and Nicholson model, integral proteins in membranes, conformational variations during ion transport, Signal transduction and molecular reception (qualitative).

Module 3

BIOPHYSICAL TECHNIQUES: Rayleigh scattering, ultra-centrifugation, viscometry. Electron microscopy (SEM-TEM, AFM), luminescence (fluorescence & phosphorescence), Calorimetry, DSC, Mass spectrometry, LCMS, MALDI-TOF, Voltage Clamp and Patch Clamp (measurements of membrane potentials).

Module 4

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Module 5

BIOMOLECULAR INTERACTIONS & MOLECULAR DYNAMICS:
Association of macromolecules, molecular conjugates, supramolecular interactions, protein-protein interactions, protein-nucleic acid interactions, lipid/membrane-protein interactions. Molecular mechanics and dynamics (Newtonian and Monte Carlo simulations), theoretical principles and its importance towards insilico simulations, results of molecular dynamics calculations and their implications to biological function.

Course Outcomes:

After studying this course, students will be able to:

• Present the foundational principles of macromolecular structure and function.
• Apply diverse techniques that enable the elucidation of molecular structure, their organization, stability, associations and functionalities.

Reference Books:

1. Biophysics – An Introduction by Cotterill, Wiley Student Edition.
2. Foundations of Biophysics by A.L. Stanford, Academic Press.
3. Principles of protein structure by G Schulz and R H Schrimer, Springer Verlag.
4. Principles of nucleic acid structure by Sanger, Springer Verlag.
5. Introduction to Protein Science by Arthur M Lesk, Oxford University Press.
6. Biological Spectroscopy by J. D. Campbell and R. A.Dwek, Plenum Press.
7. A Textbook of Biochemistry and Biophysics by S.M Gopinath, Archers & Elevators International Publishing House, India. 1st Edition, 2014.

Text Books:

1. Biophysical Chemistry by Cantor R. and Schimmel P.R, W. H. Freeman.
2. Physical Biochemistry by David Freifelder, W H Freeman and Company.
3. Biophysical Principles of Structure & Function by Fred M. Snell & Sidney Shulman.
4. Introduction to Protein Structure by Carl Branden and John Tooze, Garland Publishing.
5. Proteins Structure – A Practical Approach by Creighton, Oxford University Press.
6. Physical Chemistry: Principles and Applications in Biological Sciences by Tinoco and others, Prentice Hall.

For detail syllabus of all other subjects of BE Bt, 2017 scheme do visit Bt 4th Sem syllabus for 2017 scheme.

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