Molecular Biology BT 4th Sem Syllabus for VTU BE 2017 Scheme

Molecular Biology detail syllabus for Biotechnology (Bt), 2017 scheme is taken from VTU official website and presented for VTU students. The course code (17BT43), and for exam duration, Teaching Hr/week, Practical Hr/week, Total Marks, internal marks, theory marks, duration and credits do visit complete sem subjects post given below.

For all other bt 4th sem syllabus for be 2017 scheme vtu you can visit BT 4th Sem syllabus for BE 2017 Scheme VTU Subjects. The detail syllabus for molecular biology is as follows.

Course Objectives:

This course will enable students to

• The underlying concepts of Central Dogma and learn the mechanism of replication of DNA, Transcription of a gene and Translation of mRNA.
• Gene expression in a prokaryotic and eukaryotic cell.
• The importance of genetic recombination, damage and repair.

Module 1

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Module 2

TRANSCRIPTION: Structure and function of RNA polymerases (prokaryotes & eukaryotes), mechanism of transcription in prokaryotes and eukaryotes, transcription factors, post-transcriptional processing (RNA editing, siRNA, splicing, poly A tail and 5′ capping), transcription inhibitors.

Module 3

TRANSLATION: Mechanism of translation, activation of amino acid initiation, elongation and termination of protein synthesis. Post translational modification and protein targeting, protein splicing. Differences between prokaryotic and eukaryotic protein synthesis, inhibitors of translation.

Module 4

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Module 5

GENETIC RECOMBINATION, MUTATION & GENE MAPPING: Genetic recombination in bacteria and viruses, site specific recombination, transposons and insertion sequences; Retroviruses. DNA damage & Repair, Mutation, Role of recombination
and transposition in evolution; gene mapping techniques.

Course Outcomes:

After studying this course, students will be able to:

• Explain replication, transcription and translation processes with underlying differences in prokaryotic and eukaryotic systems.
• Elaborate importance of genetic recombination with special reference to bacterial system.
• Outline DNA damage and repair mechanisms

Reference Books:

1. Statistical methods in Bioinformatics by Warren J. Ewens, Gregory R. Grant, Springer 2nd edition, 2006.
2. An Introduction to Biostatistics by P. S. S. Sundar Rao and J. Richard, Prentice Hall of India, publications, 4th edition, 2006.
3. Biostatistics: A foundation for Analysis in the Health sciences by Wayne W. Daniel, John 7th edition, 2000.
4. A Textbook of Molecular Biology by S.M Gopinath, Archers & Elevators International Publishing House India. 1st Edition. 2014.
5. Fundamentals of Biostatistics by Veer BalaRastogi, Ane Books India.

Text Books:

1. Essentials of Molecular Biology by David Freifelder, Narosa Pub. House.
2. Molecular Biology of the Cell by Alberts et al., Garland Publishing.
3. Principles of Gene manipulation and Genomics by Primrose, Oxford University Press.
4. Molecular Biology of the Gene by James D Watson et al., Pearson Education

For detail syllabus of all other subjects of BE Bt, 2017 scheme do visit Bt 4th Sem syllabus for 2017 scheme.

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