Downstream Processing detail syllabus for Chemical Engineering (CHE), 2017 scheme is taken from VTU official website and presented for VTU students. The course code (17CH754), and for exam duration, Teaching Hr/week, Practical Hr/week, Total Marks, internal marks, theory marks, duration and credits do visit complete sem subjects post given below.
For all other che 7th sem syllabus for be 2017 scheme vtu you can visit CHE 7th Sem syllabus for BE 2017 Scheme VTU Subjects. For all other Professional Elective-IV subjects do refer to Professional Elective-IV. The detail syllabus for downstream processing is as follows.
Course Objectives:
To develop skills of the students in the area of Downstream processing with emphasis on purification of products.
Module 1
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Module 2
PRODUCT IDENTIFICATION & SEPARATION TECHNIQUES Principle and Applications of Electrophoresis – their types, Types of staining, Iso-electric focusing, ELISA (Enzyme Linked Immuno Sorbant Assay). Product Separation Techniques- ClassicalDistillation, Liquid – liquid extraction, Absorption and Adsorption, Evaporation.
Module 3
MEMBRANE SEPARATION & ENRICHMENT OPERATIONS Membrane – based separations theory; Design and configuration of membrane separationequipment; Solute polarization and cake formation in membrane ultra-filtration – causes, consequences and control techniques; Applications: Use of membrane diffusion as a tool forseparating and characterizing naturally occurring polymers; enzyme processing using ultrafiltration membranes; separation by solvent membranes; reverse osmosis. Enrichment Operations: Precipitation methods with salts, organic solvents, and polymers, extractive separations. Aqueoustwo-phase extraction, supercritical extraction; In situ product removal / integrated bioprocessing
Module 4
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Module 5
LAB TO INDUSTRIAL SCALE Considerations for scale up – All related unit operations. Concepts of Linear flow rate, volumetric flow rate, residence time in chromatographic column during scale up. Quality andregulatory aspects – (QC/QA and GLP and GMP requirements).
Course Outcomes:
After studying this course, students will be able to:
- Understand the fundamentals of downstream processing for biochemical product recovery.
- Examining traditional unit operations, as well as new concepts and emerging technologies that are likely to benefit biochemical product recovery in the future.
- Learn about various methods of separation and purification of bioproducts.
Question paper pattern:
- The question paper will have ten questions.
- Each full Question consisting of 20 marks
- There will be 2 full questions(with a maximum of four sub questions) from each module.
- Each full question will have sub questions covering all the topics under a module.
- The students will have to answer 5 full questions, selecting one full question from each module.
Graduate Attributes (as per NBA):
- Critical thinking
- Usages of modern tools
- Collaborative and multidisciplinary work
- Life long learning
- Independent and reflective learning
Text Books:
- Bioseparations: Principles and Techniques, B. Sivasankar, Published by PHI Learning Pvt. Ltd., 2006
- BioseparationTechnology, MishraNeeraj, CRC Press, 2008
Reference Books:
- Bioseparations Science and Engineering, Day, Trevor G, and Harrison, Roger G, and Rudge, Scott R, Publisher: Oxford University Press, USA, 2002
- Handbook of Bioseparations, SatinderAhuja, Published by Academic Press, 2000
- HPLC of Biological Macromolecules, M. Gooding, Fred E. Regnier, Contributor Karen M. Gooding, Fred E. Regnier, Published by CRC Press, 2002
- Isolation and Purification of Proteins, RajniHatti-Kaul, Bo Mattiasson, Published by CRC Press, 2003
- A Century of Separation Science, Haleem J. Issaq, Published by CRC Press, 2002
For detail syllabus of all other subjects of BE Che, 2017 regulation do visit Chemical Engineering 7th Sem syllabus for 2017 Regulation.
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