Bioreactor Design Concepts detail syllabus for Biotechnology (BT), 2017 scheme is taken from VTU official website and presented for VTU students. The course code (17BT742), and for exam duration, Teaching Hr/week, Practical Hr/week, Total Marks, internal marks, theory marks, duration and credits do visit complete sem subjects post given below.
For all other bt 7th sem syllabus for be 2017 scheme vtu you can visit BT 7th Sem syllabus for BE 2017 Scheme VTU Subjects. For all other Professional Elective-3 subjects do refer to Professional Elective-3. The detail syllabus for bioreactor design concepts is as follows.
Course Objectives:
This course will enable students to
- Understand the fundamentals of reactor design,
- Specify design criteria for medium sterilization
- Understand the design a complete bioreactor based on targets, constraints and physical properties.
- Apply mass and heat transfer correlations to bioreactor design.
- Identify suitable process instrumentation for monitoring and control of bioreactors.
Module 1
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Module 2
BIOREACTOR REQUIREMENTS & NON ISOTHERMAL REACTORS: Fermentation Process – General requirements; Basic design and construction of fermenters and its ancillaries; Material of construction, Vessel geometry, Bearing assemblies, Motor drives, Aseptic seals; Flow measuring devices, Valves, Agitator and Sparger Design, Sensors. Bioprocess and bioreactor design considerations for plant and animal cell cultures. Effect of media on reactor design. Non-isothermal homogeneous reactor systems. Adiabatic reactors, batch and continuous reactors, optimum temperature progression.
Module 3
MASS & HEAT TRANSFER EFFECTS: External mass transfer limitations, correlations for stirred tank, packed bed and fluidized bed reactors. Internal mass transfer limitations, correlations for stirred tank, packed bed and fluidizedbed reactors. Combined effect of heat and mass transfer effects Mass transfer in heterogeneous biochemical reaction systems; Oxygen transfer in submerged fermentation processes; Oxygen uptake rates and determination of oxygen transfer coefficients (kLa); role of aeration and agitation in oxygen transfer. Heat transfer processes in biological systems. Conceptual numericals.
Module 4
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Module 5
NOVEL BIOREACTORS DESIGN:
Design of Immobilized enzyme packed bed Reactor. Fluidized bed reactors, Slurry Reactors, Air lift & Loop reactors, Packed bed and Hollow fiber membrane bioreactors, Bioreactors for waste treatment processes; Scale-up of bioreactors, SSF bioreactors. Conceptual numericals.
Course Outcomes:
After studying this course, students will be able to:
- Design culture medium based on nutritional requirements of microbial cells.
- Specify design criterion for medium sterilization and solve problems involving both batch and continuous sterilization.
- Understand the bioreactor performance.
- Apply mass and heat transfer correlations to bioreactor design.
- Design a complete bioreactor based on targets, constraints and physical properties.
- Identify suitable process instrumentation for monitoring and control of bioreactors.
Reference Books:
- Wolf R. Vieth, Bioprocess Engineering – Kinetics, Mass Transport, Reactors and Gene Expression. A Wiley – Interscience Publication.
- Chemical Kinetic Methods: Principles of relaxation techniques by Kalidas C. New Age International.
- Chemical Reactor Analysis and Design by Forment G F and Bischoff K B., John Wiley.
Text Books:
- Contemporary Enzyme Kinetics and Mechanism by Daniel L. Purich, Melvin I. Simon, John N.Abelson
- Biochemical Engineering Fundamentals by Bailey and Ollis, McGraw Hill.
- Bioprocess Engineering by Shule and Kargi, Prentice Hall.
- Bioprocess Engineering Principles by Pauline M. Doran.
- Elements of Chemical Reaction Engineering by Fogler, H.S., Prentice Hall.
- Chemical Reaction Engineering by Levenspiel O., John Wiley.
- Chemical Engineering Kinetics by Smith J.M., McGraw Hill.
- Biocatalytic Membrane Reactor by Drioli, Taylor & Francis..
For detail syllabus of all other subjects of BE Bt, 2017 regulation do visit Biotech 7th Sem syllabus for 2017 Regulation.
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