Bioinformatics detailed Syllabus for Biotechnology Engineering (BIOTECH), 2018 scheme has been taken from the VTUs official website and presented for the VTU students. For Course Code, Subject Names, Teaching Department, Paper Setting Board, Theory Lectures, Tutorial, Practical/Drawing, Duration in Hours, CIE Marks, Total Marks, Credits and other information do visit full semester subjects post given below. The Syllabus PDF files can also be downloaded from the official website of the university.
For all other VTU BIOTECH 6th Sem Syllabus for BE 2018 Scheme, do visit VTU BIOTECH 6th Sem Syllabus for BE 2018 Scheme Subjects. The detailed Syllabus for bioinformatics is as follows.
Course Objectives:
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Module 1
DATABASES & SEQUENCE ALIGNMENT TOOLS: Introduction to Bioinformatics, Need for informatics tools and exercises, Bioinformatics resources: NCBI, EBI, ExPASy, RCSB. Significance of databases towards informatics projects. Databases and classifications. GenBank, DDBJ, EMBL, PIR, Uniprot-KB, SWISS-PROT, TrEMBL. Gene bank flat file. Protein Data Bank (PDB) flat file; FASTA Format, PIR Format; Structure file formats. the Modular Nature of proteins, Optional Alignment Methods, Substitution scores, substitution matrices, PAM, BLOSUM, Gap penalties, Statistical significance of Alignments, BLAST and its different types and function, Practical Aspect of Multiple Sequence Alignment, Progressive Alignment Methods, MUSCLE, Motifs and Patterns, PROSITE, Hidden Markov Models (HMMs), and Threading methods. Conceptual numericals.
Module 2
PHYLOGENETIC ANALYSIS AND GENOME BIOINFORMATICS Introduction to Phylogenetic analysis, rooted and unrooted trees, Elements of phylogenetic Models, Phylogenetic Data Analysis: Alignment, Substitution Model Building, Tree Building, and Tree Evaluation, Tree-Building Methods-Distance based and character based methods, Evaluating Trees and Data- Boot strapping (parametric and non-parametric), Phylogenetic softwares (CLUSTAL -omega, PHYLIP etc), Conceptual numericals. Bioinformatics tools and automation in Genome Sequencing, analysis of raw genome sequence data, Utility of EST database in sequencing, Bioinformatics in detection of Polymorphisms, SNPs and their relevance, Bioinformatics tools in microarray data analysis. Tools for comparative genomics: BLAST2, Vista, MUMmer, COG, VOG.
Module 3
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Module 4
MOLECULAR MODELING & VIZUALIZATION: Concepts in Molecular Modeling: Coordinate Systems, concept of energy minimization, different types of interactions and formulation of force fields. Basic MD algorithm, its limitations, treatment of long range forces. Comparative modeling, Constructing an initial model, refining the model, manipulating the model; molecular superposition and structural alignment,. Structure Visualization: small molecules (low molecular weight-peptides, nucleotides, disaccharides, simple drugs molecules) and macromolecules (high molecular weight molecules-proteins, DNA, RNA, membranes). Usages of visualization software available in public domain like VMD, Rasmol, Pymol, SpdbViewer, and Cn3D.
Module 5
PLASMID MAPPING, PRIMER DESIGN AND INSILICO DRUG DESIGN:
Restriction mapping, Utilities, DNA strider, MacVector and OMIGA, gene construction KIT, Vector NTI, Web based tools (MAP, REBASE); Primer design-need for tools, Primer design programs and software (PRIME3). Molecular modeling in drug discovery, molecular docking, quantitative structure-activity relationship (QSAR), deriving the Pharmacophoric Pattern, Receptor Mapping, Estimating Biological Activities, Ligand-Receptor Interactions: Docking softwares (AUTODOCK, HEX), Energy Calculations (no derivation). Conceptual numericals.
Course Outcomes:
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Question paper pattern:
- The question paper will have ten full questions carryin
- Each full question will be for 20 marks.
- There will be two full questions (with a maximum of fo
- Each full question will have sub- question covering all
- The students will have to answer five full questions, se equal marks. ur sub- questions) from each module. the topics under a module. lecting one full question from each module.
Text Books:
- Computational methods for macromolecular sequence analysis: R F Doolittle. Acad. Press. 1996
- Bioinformatics: Methods And Applications P aragRastogi and S.C. Rastogi PHI Fourth Edition 2004
Reference Books:
For the complete Syllabus, results, class timetable, and many other features kindly download the iStudy App
It is a lightweight, easy to use, no images, and no pdfs platform to make students’s lives easier..
For detail Syllabus of all other subjects of BE 6th Sem Biotechnology Engineering, visit (BIOTECH) 6th Sem Syllabus Subjects.
For all (CBSE & Non-CBSC) BE results, visit VTU BE all semester results direct links.