Genomics & Proteomics detailed Syllabus for Biotechnology Engineering (BIOTECH), 2018 scheme has been taken from the VTUs official website and presented for the VTU students. For Course Code, Subject Names, Teaching Department, Paper Setting Board, Theory Lectures, Tutorial, Practical/Drawing, Duration in Hours, CIE Marks, Total Marks, Credits and other information do visit full semester subjects post given below. The Syllabus PDF files can also be downloaded from the official website of the university.
For all other VTU BIOTECH 5th Sem Syllabus for BE 2018 Scheme, do visit VTU BIOTECH 5th Sem Syllabus for BE 2018 Scheme Subjects. The detailed Syllabus for genomics & proteomics is as follows.
Course Objectives:
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Module 1
INTRODUCTION: Genes and Proteins, Polymorphisms-types of polymorphism, genome sequences and database subscriptions, discovery of new genes and their function. Early sequencing efforts. Extraction of DNA, Methods of preparing genomic DNA for sequencing, DNA sequence analysis methods-Maxam& Gilbert Method, Sanger Di-deoxy method, Fluorescence method, shot-gun approach. NGS-different methods and principles
Module 2
GENOMICS: Inheritance pattern in eukaryotes, Mutations, Gene variation and Single Nucleotide Polymorphisms (SNPs), Expressed sequenced tags (ESTs), Gene-disease association, diagnostic genes and drug targets, genotyping tools-DNA Chips, diagnostic assays, diagnostic services. Functional genomic studies with model systems such as Drosophila, Yeast or C. elegans. Genome projects on E.coli., Arabidopsis and rice; Human genome project and the genetic map.
Module 3
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Module 4
GENOME ANALYSIS : Genetic and physical maps: Breeding requirements for mapping. Molecular markers-RFLP, RAPD, AFLP, SCAR, CAPS, microsatellites and SNPs. Methods of molecular mapping, Marker assisted selection. Mapbased cloning, T-DNA and transposon tagging. Differential display via RT-PCR. Micro-array in functional genomics. Bioinformatics analysis-clustering methods. FISH-DNA amplification markers; Telomerase as molecular markers. STS mapping.
Module 5
PROTEOMICS : Introduction to proteins, Large scale preparation of proteins and peptides, Merrifield Synthesis of peptides, use of peptides as probes.proteins as drugs; two hybrid interaction screens. Mass-spec based analysis of protein expression. “Protein Chip”-interactions and detection techniques. Two dimensional PAGE for proteome analysis, Detection of proteins on SDS gels, Protein cleavage, Edman protein microsequencing, Automation in proteomics, Applications of proteome analysis to drug development and toxicology, Phage antibodies as tools for proteomics.
Course Outcomes:
For the complete Syllabus, results, class timetable, and many other features kindly download the iStudy App
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Question paper pattern:
- The question paper will have ten full questions carryin
- Each full question will be for 20 marks.
- There will be two full questions (with a maximum of fo
- Each full question will have sub- question covering all
- The students will have to answer five full questions, se equal marks. ur sub- questions) from each module. the topics under a module. lecting one full question from each module.
Text Books:
- Introduction to Genomics Arthur M Lesk Oxford University Press 2007
- Discovering Genomics, Proteomics & Bioinformatics A M Campbell & L J Heyer Pearson Education, 2007
- Proteins and Proteomics Richard J Simpson IK International 2003
Reference Books:
For the complete Syllabus, results, class timetable, and many other features kindly download the iStudy App
It is a lightweight, easy to use, no images, and no pdfs platform to make students’s lives easier..
For detail Syllabus of all other subjects of BE 5th Sem Biotechnology Engineering, visit (BIOTECH) 5th Sem Syllabus Subjects.
For all (CBSE & Non-CBSC) BE results, visit VTU BE all semester results direct links.