Advanced Instrumental Analysis Detailed Syllabus for Pharmaceutical Analysis M.Pharm first year second sem is covered here. This gives the details about credits, number of hours and other details along with reference books for the course.
The detailed syllabus for Advanced Instrumental Analysis M.Pharm 2017-2018 (R17) first year second sem is as follows.
M.Pharm. I Year II Sem.
Course Objectives: This subject deals with various hyphenated analytical instrumental techniques for identification, characterization, and quantification of drugs. Instruments dealtare LC-MS, GC-MS, and hyphenated techniques.
Course Outcome: By the completion of topics the students will come out with the thorough knowledge of various spectral aspects of X-Ray, IR, SEM, ORD etc which help them in further projects works and also industrial opportunities.
UNIT – I : X-Ray diffraction methods: Origin of X-rays, basic aspects of crystals, X-ray crystallography, miller indices, rotating crystal techniques, single crystal diffraction, power diffraction, structural elucidation and applications.
UNIT – II
- Biochromatography: Size exclusion chromatography, ion exchange chromatography, ion pair chromatography, affinity chromatography general principles, stationary phases and mobile phases.
- Super critical fluid chromatography: Principles, instrumentation, pharmaceutical applications.
- Raman: Principle (absorption, diffraction, scattering and emission of wave, molecular interaction), instrumentation (Dispersive Raman, FT-Raman), advantage and disadvantage, pharmaceutical applications including detection of counterfeit
UNIT – III : Capillary electrophoresis: Overview of CE in pharmaceuticalanalysis, basic configuration, CE characteristics, principles of CE, methods and modes of CE. General considerations and method Development in CE,
UNIT – IV
- DSC: Principle, thermal transitions, instrumentation (Heat flux and power- compensation designs), Modulated DSC, Hyper DSC, experimental parameters (sample preparation, experimental conditions, calibration, heating and cooling rates, resolution, Sources of errors) and their influence, advantages and disadvantages, pharmaceutical applications.
- DTA: Principle, instrumentation, advantage and disadvantage, pharmaceutical application, derivative differential thermal analysis (DDTA).
- TGA: Principle, instrumentation, factors affecting results, advantages and disadvantages, pharmaceutical application.
UNIT – V
- Scanning electron microscope (SEM): Principles, Instrumentation and applications.
- Optical Rotatory Dispersion (ORD), Circular Dichroism, Cotton effect, Octane rule and applications.
REFERENCES:
- Instrumental Methods of Chemical Analysis by B.K Sharma
- Organic spectroscopy by Y.R Sharma
- A Text book of Pharmaceutical Analysis by Kerrenth A. ConnorsVogel’s Text book of Quantitative Chemical Analysis by A.I. Vogel
- Practical Pharmaceutical Chemistry by A.H. Beckett and J.B. Stenlake
- Organic Chemistry by I. L. Finar
- Organic spectroscopy by William Kemp
- Quantitative Analysis of Drugs by D. C. Garrett
- Quantitative Analysis of Drugs in Pharmaceutical Formulations by P. D. Sethi
- Spectrophotometric identification of Organic Compounds by Silverstein
- HPTLC by P.D. Seth
- Spectroscopy by Donald L Pavia, Gary M Lampman, George S Kriz, James A Vyvyan
For all other M.Pharm 1st Year 2nd Sem syllabus go to JNTUH M.Pharm Pharmaceutical Analysis 1st Year 2nd Sem Course Structure for (R17) Batch.
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