Advanced Physical Pharmaceutics Detailed Syllabus for Pharmaceutics / Pharmaceutical Technology M.Pharm first year first sem is covered here. This gives the details about credits, number of hours and other details along with reference books for the course.
The detailed syllabus for Advanced Physical Pharmaceutics M.Pharm 2017-2018 (R17) first year first sem is as follows.
M.Pharm. I Year I Sem.
Course Objective: The students shall apply the principles of physical and chemical properties of particle science, polymer science and their use in pharmaceutical dosage forms. They also learn the compression and consolidation parameters for powders and granules. Students also learn about the rheology, disperse systems, dissolution and solubility related parameters for dosage forms.
Course Outcome: The students will learn particle size analysis method, solid dispersion, physics of tablets, polymer classification and its applications, student will also practice the stability calculations, shelf life calculations and accelerated stability studies. They also understand the rheology, absorption related to liquids and semi-solid dosage forms with advances. They also know the factors affecting the dissolution and solubility in related to invitro/invivo correlations.
UNIT – I : Polymer science: Classification, properties and characterization of polymers, phase separation, polymers in solid state, preparation of polymer solution, application of polymers in pharmaceutical formulations. Mechanism of biodegradation of biodegradable polymers including controlled drug delivery systems, Mucoadhesive, Hydrodynamically balanced and Transdermal Systems.
UNIT – II : Physics of tablet compression: Basic principles of interactions, compression and consolidation,
compression and consolidation under high loads, effect of friction, distribution of forces in compaction, force volume relationships, Heckel plots, compaction profiles, energy involved in compaction, Measurement of compression with strain gauges, compression pressure-QA parameters.
UNIT – III : Kinetics and drug stability: Stability calculations, rate equations, complex order kinetics, Factors influencing stability, strategy of stability testing, method of stabilization, method of accelerated stability testing in dosage forms, temperature and humidity control, physical stability testing of pharmaceutical products. Photodecomposition and solid state decomposition.
UNIT – IV : Viscoelasticity: Theoretical consideration, instrumentation, rheological properties of disperse systems and semisolids. Oscillatory testing, Creep measurement. Characterization of API and excipients: Differential Scanning Calorimetry: Principle, thermal transitions, advantages, disadvantages, instrumentation, applications, and interpretations X Ray Diffraction methods: Origin of x-rays, applications, advantages, disadvantages instrumentation, applications, and interpretations..
UNIT – V : Dissolution and solubility: Solubility and solubilization of nonelectrolytes, solubilization by the use of surfactants, cosolvents, complexation, drug derivatisation and solid state manipulation, Mechanisms of Drug release – dissolution, diffusion (Matrix and Reservoir) and swelling controlled (Peppas Model) and dissolution equipment.
TEXT BOOKS:
- Physical Pharmacy, 4th Edition by Alfred Martin.
- Theory and Practice of Tablets – Lachman Vol.4
- Pharmaceutical Dosage forms – Disperse systems Vol. I & II
- Cartenson “Drug Stability, Marcel Decker Solid state properties, Marcel Dekker.
- Industrial Pharmacy – Selected Topics, CVS Subramanyam and J Thimmasetty, Vallabha Prakashan Delhi – 2013
REFERENCE BOOKS:
- Dispersive systems I, II, and III
- Robinson. Controlled Drug Delivery Systems
For all other M.Pharm 1st Year 1st Sem syllabus go to JNTUH M.Pharm Pharmaceutics / Pharmaceutical Technology 1st Year 1st Sem Course Structure for (R17) Batch.
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