Advanced Organic Chemistry -II Detailed Syllabus for Pharmaceutical Chemistry M.Pharm first year second sem is covered here. This gives the details about credits, number of hours and other details along with reference books for the course.
The detailed syllabus for Advanced Organic Chemistry -II M.Pharm 2017-2018 (R17) first year second sem is as follows.
M.Pharm. I Year II Sem.
Course Objective: The content of Unit I and II are mainly aimed at utilization of different synthetic reagents used in the preparation of intermediates and final compounds and also aimed at the principles of green chemistry. Unit III and IV contents are mainly aimed at scale of processes for the preparation of new pharmaceutical agents and also to design different synthetic strategies. Unit V is mainly aimed to utilize the knowledge of chemical library for drug design.
UNIT I : Synthetic Reagents & Applications: Lead Tetra Acetate (LTA), N- Bromosuccinimide (NBS), Osmium Tetroxide, Lithium Aluminum Hydride (LAH) and Sodium Borohydride, Dicyclohexylcarbodimide (DCC) and 2,3-dichlro-5,6-dicyano-1,4-benzoquinone (DDQ). A brief account on Green Chemistry: Principles and applications
UNIT II : Catalysis:
- Types of catalysis, heterogeneous and homogenous catalysis, advantages and disadvantages
- Heterogeneous catalysis – preparation, characterization, kinetics, supported catalysts, catalyst deactivation, and regeneration, some examples of heterogeneous catalysis used in synthesis of drugs.
- Homogenous catalysis, hydrogenation, hydroformylation, hydrocyanation, Wilkinson catalysts, chiral ligands and chiral induction, Ziegler‐Natta catalysts, some examples of homogenous catalysis used in synthesis of drugs
- Transition-metal and Organo-catalysis in organic synthesis: Metal-catalyzed reactions
- Biocatalysis: Use of enzymes in organic synthesis, immobilized enzymes/cells in organic reaction.
- Phase transfer catalysis ‐theory and applications
UNIT III : Molecular Rearrangements & their applications:
- Carbon to Carbon Migration: Wagner – Meerwin rearrangement, Claisen rearrangement, and benzil – benzilic acid rearrangement.
- Carbon to Nitrogen Migration: Hoffmann rearrangement, Curtius rearrangement and Lossen rearrangement, Beckman rearrangement.
- Carbon to Oxygen Migration: Bayor – Villiger rearrangement, Rearrangement of hydro peroxides and Wittig rearrangement.
UNIT IV : Chemistry of peptides
- Coupling reactions in peptide synthesis
- Principles of solid phase peptide synthesis, t-BOC and FMOC protocols, various solid supports and linkers: Activation procedures, peptide bond formation, deprotection and cleavage from resin, low and high HF cleavage protocols, formation of free peptides and peptide amides, purification and case studies, site-specific chemical modifications of peptides
- Segment and sequential strategies for solution phase peptide synthesis with any two case studies
- Side reactions in peptide synthesis: Deletion peptides, side reactions initiated by proton abstraction, protonation, over activation and side reactions of individual amino acids.
UNIT V : Combinatorial Chemistry: Introduction, solid phase techniques, parallel synthesis, mixed combinatorial chemistry, diconvulution techniques, tagging, photolithography, limitations of combinatorial chemistry, planning and designing of combinatorial synthesis.
Outcome: The student would be in a position to have advanced knowledge of different synthetic reagents and reaction processes, synthetic routes by involving green chemistry principles. The student would also have techniques to utilize the chemical library of combinatorial chemistry.
RECOMMENDED BOOKS
- W. Carruthers , Some Modern Methods of Org. Synthesis , III rd Edition , Cambridge University Press, Cambridge(1988)
- Gorgy Keri and Istarian Toth , Molecular Patho-mechanisms and New Trends in Drug Research – Taylor and Francis Group ,London 2003
- R.K. Mackie , A Guidebook to Organic Thesis – Prentice Hall
- T.W. Greene and PGM Warts ,Protecting Groups – John Willey
- Michael B. Smith , Organic Synthesis
- Organic synthesis- Special techniques VK Ahluwalia and R Aggarwal, Narosa Publishers.
- “Organic Chemistry” Vol I and II. I. L. Finar. ELBS, Sixth ed., 1995.
- “Advanced Organic chemistry, Reaction, mechanisms and structure”, JMarch, John Wiley and sons, New York.
- Principles of organic synthesis, ROCNorman and JMCoxan, Nelson thorns
- Carey, Organic chemistry, 5th edition (Viva Books Pvt. Ltd.)
For all other M.Pharm 1st Year 2nd Sem syllabus go to JNTUH M.Pharm Pharmaceutical Chemistry 1st Year 2nd Sem Course Structure for (R17) Batch.
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