Bioseperation & Down Stream Processing detail syllabus for Biotechnology (Biotech), 2019-20 scheme is taken from AKTU official website and presented for AKTU students. The course code (RBT702), and for exam duration, Teaching Hr/Week, Practical Hr/Week, Total Marks, internal marks, theory marks, duration, and credits do visit complete sem subjects post given below.
For all other biotech 7th sem syllabus for b.tech 2019-20 scheme aktu you can visit Biotech 7th Sem syllabus for B.Tech 2019-20 Scheme AKTU Subjects. The detail syllabus for bioseperation & down stream processing is as follows.
Unit I
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Unit II
Removal of Insoubles
Cell disruption methods for intracellular products: Physical, chemical and mechanical – Removal of insolubles: Biomass and particulate debris separation techniques – flocculation – sedimentation – centrifugation and filtration methods.
Unit III
Isolation of Products
Adsorption: Principles – Langumir – Freundlich isotherms – Extraction: Basics- Batch and continuous, aqueous two-phase extraction – supercritical extraction – in situ product removal -Precipitation: Methods of precipitation with salts – organic solvents and polymers – Membrane based separations: Micro and ultra filtration – theory – design and configuration of membrane separation equipments and its applications.
Unit IV
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Unit V
Product Polishing
Crystallization: Principles-Nucleation-Crystal growth-Kinetics-Batch crystallizers: Scale-up and design, Drying: Principles-Water in biological solids- Heat and mass transfer-Drying equipments: description and operation-Vacuum shelf – rotary dryer-Freeze dryer-Spray dryer. Biomolecules of Commercial importance Ethanol, citric acid, lysine, steroids, penicillin, dextran, trehalose, subtilisin, chymosin, vitamin B12, hepatitis B vaccine, insulin, erythropoietin, monoclonal antibodies.
Text Books:
- Roger G. Harrison, Paul Todd, Scott R. Rudge, Demetri P. Petrides, “Bio separation Science and Engineering” Oxford University press, 2003.
- Belter PA and Cussler E, “Bioseparations”, Wiley, 1985.
- Protein: Biochemistry and Biotechnology by Gary Walsh (2002 John Wiley & Sons Ltd.)
- Process Biotechnology Fundamentals by S.N. Mukhopadhyay (2001). Viva Books Private Limited.
- Schuler & Kargi, Bio-process Engg. PHI
- Keith Wilson and John Walker, Practical BiochemistryPrinciples and Techniques, Cambridge, 5th Ed.2000
- Coulson & Richardson’s Chemical Engineering – Volume 3 (Chemical and Biochemical Reactors and process controls) ed. Richardson, J.F., Peacock, D.G., First Indian ed. Asian Books Pvt. Ltd. 1998.
- Bailey & oils, Biochemical Engg. Fundamentals, McGraw-Hill, 1990
- Geankoplis, C.J. Transport Processes and Unit Operations Prentice Hall of (I) 3rd ed. 1997.
- Mukhopadhyay, S.N. Process Biotechnology Fundamentals, Viva Books Pvt. Ltd. 2001.
- Muni & Cheryan, Handbook of Ultrafiltration
Reference Books:
- Raja Ghosh, Principles of Bioseparations Engineering, World Scientific Publishing, 2006.
- Ladisch.M.R, “Bioseparation Engineering: Principles, Practice and Economics”, John Wiley & sons, New York, 2001.
- Asenjo.J.M, “Separation processes in Biotechnology” Marcel Dekker Inc.1993.
For detail syllabus of all other subjects of B.Tech Biotech, 2019-20 scheme do visit Biotech 7th Sem syllabus for 2019-20 scheme.
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