Biomarker & Diagnostics detail syllabus for Biotechnology (Biotech), 2019-20 scheme is taken from AKTU official website and presented for AKTU students. The course code (RBT062), and for exam duration, Teaching Hr/Week, Practical Hr/Week, Total Marks, internal marks, theory marks, and credits do visit complete sem subjects post given below.
For all other biotech 6th sem syllabus for b.tech 2019-20 scheme aktu you can visit Biotech 6th Sem syllabus for B.Tech 2019-20 Scheme AKTU Subjects. For all other Departmental Elective-II subjects do refer to Departmental Elective-II. The detail syllabus for biomarker & diagnostics is as follows.
Unit I
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Unit II
Molecular Oncology Mitochondrial disorders: Cancer – Benign and Malignant neoplasms, multifactorial disposition, Cancer pathogenesis, positive and negative mediators of neoplastic development, Proto-oncogenes, Oncogenes and Tumor suppressors.Allele loss and loss of Heterozygosity.Mitochondrial inheritance, Mitochondrial myopathy, lactic acidosis, MELAS, LHONs, identity testing.
Unit III
Biomarkers in disease diagnostics: FDA definition of disease markers, Role of markers in Disease diagnosis. Approaches and methods in the identification of disease markers, predictive value, diagnostic value, emerging blood markers for sepsis, tumour & cancer markers, markers in inflammation and diagnosis of cytoskeletal disorders.
Unit IV
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Unit V
Genomic instability, Chromosome mapping & Genome plasticity: Common fragile sites and methods of induction, Heritable fragile sites and FXS. GenomicInstability, mechanism and diseases. Trinucleotide Repeats;Mechanism of expansion and triplet repeats and related disorders.Genetic linkage maps, Relation to the probability of recombination, Pedigree analysis with genetic markers and overview of human genome project.
Reference Books:
- Molecular biology of the cell. Bruce Alberts, 6th Edition
- Principles of tissue engineering. Robert Lanza. Elsevier Publications.
- Introduction to Tissue engineering, applications and challenges. Ravi Birla. Wiley Publications.
- Molecular Cell Biology: Darnell J, Lodish H and Baltimore D
- Cell and Molecular Biology: De Robertis EDP and De Robertis EMF
- Animal cell culture: Ian Freshney
- An introduction to Human Molecular Genetics by Pasternak et al., John Wiley & Sons
- Human Chromosomes by Miller & Tharman, Springer Publishing Company,
- Molecular Biology of the cell by Alberts et al., Garland Press
- Genes IX, by Lewin B, Pearson India
- Cell and Molecular Biology by De Robertis and De Robertis, Lipincott &Wilkins
- Genome III by Brown TA, Garland Press
- Elements of medical Genetics by Turnpenny and Ellard, Churchill Livingstone
For detail syllabus of all other subjects of B.Tech Biotech, 2019-20 regulation do visit Biotech 6th Sem syllabus for 2019-20 Regulation.
Don’t forget to download iStudy for the latest syllabus, results, class timetable and more.