BTE6022: Protein Syllabus for BT 6th Sem 2018 Pattern Mumbai University (Elective-2)

Protein detailed syllabus scheme for Biotechnology (BT), 2018 regulation has been taken from the MU official website and presented for the Bachelor of Engineering students. For Course Code, Course Title, Test 1, Test 2, Avg, End Sem Exam, Team Work, Practical, Oral, Total, and other information, do visit full semester subjects post given below.

For 6th Sem Scheme of Biotechnology (BT), 2018 Pattern, do visit BT 6th Sem Scheme, 2018 Pattern. For the Elective-2 scheme of 6th Sem 2018 regulation, refer to BT 6th Sem Elective-2 Scheme 2018 Pattern. The detail syllabus for protein is as follows.

Protein Syllabus for Biotechnology TE 6th Sem 2018 Pattern Mumbai University

Protein

Prerequisites:

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Course Objectives:

Imparting knowledge about structure function relationships of proteins
Studying the problem of protein folding and methods of characterization folded proteins
Aspects of Protein Engineering in the industry

Course Outcomes:

At the end the student would have learned:
Structure and Function relationship in proteins and its application in designing proteins
Process of engineering proteins to increase its value by assisting folding, purification
Protein engineering of therapeutic proteins, industrially important enzymes and antibodies.

Module 1

Primary, Secondary, Tertiary and Quaternary Structure of Proteins, Bonds that stabilize a protein molecule, Ramchandran Plot. Protein folding pathways and Energy Status of a Protein Molecule, Protein Degradation in the cell 06

Module 2

Module 3

Structure Function Relationships in Proteins: Helix-turn-Helix motif in DNA binding and homeo domain protein, Zinc fingers, Leucine zippers. Membrane proteins: General characteristics, Transmembrane segments, bacteriorhodopsin and Photosynthetic reaction center 06

Module 4

Concepts of designing a new Protein Molecule: Chemical synthesis of peptides. Target molecules for Protein Engineering. The protein cycle and steps involved in Engineering a new Protein. De novo protein design 06

Module 5

Applications of Protein Engineering: Protein Engineering to enhance the solubility and assist 10 folding of expressed proteins. Protein Engineering to assist purification of expressed proteins. Role in Vaccine Development. Engineering blood clotting factors:f actor VIII. Engineering enzymes: tyrosyl- t RNA synthase. Engineering therapuetic hormones: insulin. Engineering humanized antibodies

Term work

Assessment

Internal

Assessment consists of two tests which should be conducted at proper intervals.

End Semester theory examination

Question paper will comprise of 6 questions each carrying 20 questions.
Total 4 questions need to be solved
Question no.1 will be compulsory based on entire syllabus wherein sub questions can be asked.
Remaining questions will be randomly selected from all the modules
Weightage of marks should be proportional to number of hours assigned to each module

Reference Books:

Lilia Arbenghina; Protein Engineering in Industrial Biotechnology; Harwood Academic Publishers
Creghton TE; Proteins Function, A Practical Approach; Freeman WH, Second Ed, 1993
Branden C. And Tooze J.; Introduction to Protein Structure; Second Edition, Garland Publishing, NY, USA, 1999
Moody PCE, and A.J. Wilkinson; Protein Engineering; IRL Press, Oxford, 1990
Walsh.G; Protein Biotechnology and Biochemistry; 2nd ed.; Wiley Publications
Klaus Demobowsky, Novel Therapeutic Proteins; Wiley Publications
Voet D. and Voet G.; Biochemistry Third Edn. John Wiley and Sons, 2001

For detail Syllabus of all subjects of Biotechnology (BT) 6th Sem 2018 regulation, visit BT 6th Sem Subjects of 2018 Pattern.

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