Bioseperation & Downstream Processing Technology-I detailed syllabus scheme for Biotechnology (BT), 2019 regulation has been taken from the University of Mumbai official website and presented for the Bachelor of Engineering students. For Course Code, Course Title, Test 1, Test 2, Avg, End Sem Exam, Team Work, Practical, Oral, Total, and other information, do visit full semester subjects post given below.
For all other Mumbai University Biotechnology 7th Sem Syllabus 2019 Pattern, do visit BT 7th Sem 2019 Pattern Scheme. The detailed syllabus scheme for bioseperation & downstream processing technology-i is as follows.
Bioseperation & Downstream Processing Technology-I Syllabus for Biotechnology BE 7th Sem 2019 Pattern Mumbai University
Prerequisites:
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Course Objectives:
- To cover the fundamentals, and design concepts of various downstream purification steps (unit operations) involved in a biochemical process.
Course Outcomes:
- Students will be able to describe theory, principle, design, application and possible integrations of unit operations in bioprocessing.
Module 1
Introduction to By-products and Bio separation: Range and characteristics of bio products, Characteristics of Fermentation Broth, Selection of unit operation with due consideration of physical, chemical and biochemical aspect of biomolecules. Stages of Downstream Processing 04
Module 2
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Module 3
Primary Separation: Removal of insolubles and Biomass (and particulate debris) separation techniques, Flocculation and sedimentation, Centrifugation-Ultracentrifugation, Gradient centrifugation, Filtration: Theory of Filtration, Pre-treatment of Fermentation Broth, Filter Media and Equipment, Conventional and Cross-flow Filtration, Continuous Filtration, Filter cake resistance, specific cake resistance, Washing and dewatering of filter cakes 09
Module 4
Gas Absorption: Solubility of gases in liquids, Effect of temperature and pressure on solubility, Ideal and Non-ideal solutions, Choice of solvent for gas absorption, absorption factor, stripping factor, minimum gas liq ratio, Single stage gas absorptionCross Current, Co- current, Countercurrent, Multistage Counter current Operation, Absorption with Chemical Reactions, Related problems 10
Module 5
Liquid-Liquid Separation Process: Introduction to Liquid-Liquid Extraction, Choice of Solvent for Liquid-Liquid Extraction, Binodal solubility curve, Single Stage Operation, Equipments for liquid-liquid extraction. Types of extraction processes: Reactive extraction, Aqueous two phase systems, Reverse micellar extraction, Liquidliquid and solid-liquid extraction, Supercritical fluid Extraction. Design of extraction equipment. Different types of extractors and designing of extractors. Distillation: Simple, Steam and Equilibrium distillation, Fractionation, Mccabe Thiele method, azotropes, numericals
Module 6
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Term work
Term work shall consist of minimum eight tutorials from entire syllabus which are to be given at regular intervals Batch wise. Tutorials: 20 marks Attendance: 05 marks Total: 25 Marks
Assessment
Internal
- Assessment consists of two tests which should be conducted at proper intervals.
End Semester theory examination
- Question paper will comprise of 6 questions each carrying 20 questions.
- Total 4 questions need to be solved
- Question no.1 will be compulsory based on entire syllabus wherein sub questions can be asked.
- Remaining questions will be randomly selected from all the modules
- Weightage of marks should be proportional to number of hours assigned to each module
Reference Books:
- Treybal R.E. , Mass transfer operation, 3 Ed., McGraw Hill New York, 1980.
- McCabe W. L.and Smith J.C., Unit operation in chemical engineering, 5Ed., McGraw Hill New York 1993.
- Geankoplis C.J., Transport processed and unit operations, Prentice Hall, New Delhi 1997.
- Roger G. Harrison, Paul Todd, ScottR. Rudge, Demetri P. Petrides, Bioseparations Science and Engineering, Oxford University Press
- B.Shivshankar, Bioseparations: Principles and Techniques, Eastern Economy Edition, PHI Learning Pvt. Ltd., Publishing House, New Delhi, 2012
- Bioseparation & bioprocessing (2nd Ed) 2-Volume set, Ed SUBRAMANIAN Ganapathy, Wiley-VCH, ( 09-2007)
- P.A. Belter, E.L. Cussler and Wei-Shou Hu., Bioseparations-Downstream Processing for Biotechnology, Wiley Interscience Publication, 1988.
- J.E. Baileyand D.F. Ollis, Biochemical Engineering Fundamentals, 2nd Edition, McGraw Hill, Inc., 1986.
- R. K. Scopes, Berlin, Protein Purification: Principles and Practice, Springer, 1982.
- Scopes Ak, Protein Purification, IRL Press, 1993
- Biotechnology: Bioprocessing, Rhem and Reed, Vol. 3, 1993
- Separation and purification techniques in biotechnology, Fredreich Dechow, 1989
- Asenjo J.A. and J.Hong (Eds), Separation Processes in Biotechnolgy, Taylor and Francis
- T. Schepler et al, Biotreatment, Downstream Processing and Modeling (Advances in Biochemical Engineering /Biotechnology, Vol 56) by Springer Verlag
For detail syllabus of all other subjects of Biotechnology (BT) 7th Sem 2019 regulation, visit BT 7th Sem Subjects syllabus for 2019 regulation.