Molecular Genetics detailed syllabus scheme for Biotechnology (BT), 2017 regulation has been taken from the University of Mumbai official website and presented for the Bachelor of Engineering students. For Course Code, Course Title, Test 1, Test 2, Avg, End Sem Exam, Team Work, Practical, Oral, Total, and other information, do visit full semester subjects post given below.
For all other Mumbai University Biotechnology 4th Sem Syllabus 2017 Pattern, do visit BT 4th Sem 2017 Pattern Scheme. The detailed syllabus scheme for molecular genetics is as follows.
Molecular Genetics Syllabus for Biotechnology SE 4th Sem 2017 Pattern Mumbai University
Prerequisites:
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Course Objectives:
- Understand the Central Dogma of gene expression
- Explain the foundations of Mendelian genetics and chromosomal theory and apply these, with appropriate terminology, to contemporary concepts in genetics.
- Understand the redundant and universal qualities of the genetic code and how it is used to determine the amino acid sequence of a polypeptide.
- Describe the processes of transcription and translation in both prokaryotes and eukaryotes at the molecular level.
- Describe how prokaryotes control their gene expression through positive and negative regulatory mechanisms.
Course Outcomes:
- Students will get knowledge of molecular biology and genetics of Prokaryotic and eukaryotic organisms.
- Students will get insight on Replication, Transcription and translation processes in prokaryotes and eukaryotes, various mutations, their Repair mechanisms. Genetic syndromes.
Module 1
Structure of Nucleic Acid:
- DNA, RNA: mRNA,tRNA, rRNA,
- Denaturation and Renaturation of DNA,
- Tm, GC content from Tm,
- Complexity of DNA, Cot curves
- Satellite DNA: Repetitive DNA, SNP, STR 04
Module 2
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Module 3
Cytogenetics
- International System for Human Chromosome Nomenclature
- Mechanisms of numerical and structural chromosomal aberrations
- Chromosomal and non-chromosomal basis of sex determination
- Syndromes – Downs, Turner, Cri Du Chat, Klinfelter Transposons
- Fluorescence in-situ hybridization technique and applications 04
Module 4
DNA Replication and Repair:
- Prokaryotic and Eukaryotic DNA replication mechanism -Enzymes and accessory proteins involved in DNA replication ,
- DNA Mutations: Types of Mutations and Mutagens
- DNA Repair Mechanism – Excision, recombinational, SOS, Photo reactivation, Mis-match repair 06
Module 5
Transcription
- Relationship between Genes and Proteins
- Prokaryotic transcription
- Eukaryotic transcription: Eukaryotic RNA Polymerases, Transcription of protein coding genes, Production of mature mRNAs in Eukaryotes- 5′ Modification , 3′ Modification , Intron splicing, RNA Editing 05
Module 6
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Module 7
Regulation of gene expression
- Operon theory
- lac Operon: Structure, Regulation of Lac genes, Positive control of Lac Operon
- trp Operon: Gene organization of the tryptophan biosynthetic genes, Regulation of the trp operon, attenuation
- ara operon: structure and regulation of ara operon 05
Term work
Term work shall consist of minimum eight tutorials from entire syllabus which are to be given at regular intervals Batch wise. Tutorials: 20 marks Attendance: 05 marks Total: 25 marks
Assessment
Internal:
- Assessment consists of average of two tests which should be conducted at proper interval.
End Semester theory examination
- Question paper will comprise of 6 questions, each carrying 20 marks.
- Total 4 questions need to be solved.
- Question No.1 will be compulsory and based on entire syllabus wherein sub questions can be asked.
- Remaining questions will be randomly selected from all the modules. Weightage of marks should be proportional to number of hours assigned to each Module
Reference Books:
For the complete Syllabus, results, class timetable, and many other features kindly download the iStudy App
It is a lightweight, easy to use, no images, and no pdf platform to make students’s lives easier..
For detail syllabus of all other subjects of Biotechnology (BT) 4th Sem 2017 regulation, visit BT 4th Sem Subjects syllabus for 2017 regulation.