BP601T: Medicinal Chemistry III – Theory Syllabus for B.Pharm 6th Sem 2019 Pattern Mumbai University

Medicinal Chemistry III – Theory detailed Syllabus Scheme for Bachelor of Pharmacy (B.Pharm), 2019 regulation has been taken from the University of Mumbai official website and presented for the Pharmacy students. For Course Code, Subject Name, Continuous Mode, SE Marks, SE Duration, Total, Marks, Duration in Hours, Total Marks, and other information, do visit full semester subjects post given below.

For all other Mumbai University B.Pharm 6th Sem Syllabus 2019 Pattern, do visit B.Pharm 6th Sem 2019 Pattern Scheme. The detailed syllabus scheme for medicinal chemistry iii – theory is as follows.

BP601T: Medicinal Chemistry III – Theory Syllabus for B.Pharm 6th Sem 2019 Pattern Mumbai University

Scope:

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Objectives

Upon completion of the course student shall be able to

1. Understand the importance of drug design and different techniques of drug design.
2. Understand the chemistry of drugs with respect to their biological activity.
3. Know the metabolism, adverse effects and therapeutic value of drugs.
4. Know the importance of SAR of drugs.

UNIT I 10

Antibiotics Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes.

1. P-Lactam antibiotics: Penicillin, Cepholosporins, P Lactamase inhibitors,Monobactams
2. Aminoglycosides: Streptomycin, Neomycin, Kanamycin
3. T etracyclines: Tetracycline,Oxytetracycline,Chlortetracycline,Minocycl ine, Doxycycline

UNIT II 10

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UNIT III 10

1. Anti-tubercular Agents :
   1. Synthetic anti tubercular agents: Isoniozid*, Ethionamide, Ethambutol,Pyrazinamide, Para amino salicylic acid.*
   2. Anti-tubercular antibiotics: Rifampicin, Rifabutin, CycloserineStreptomycine, Capreomycin sulphate. 3
2. Urinary tract anti-infective agents :
   1. Quinolones: SAR of quinolones, Nalidixic Acid,Norfloxacin, Enoxacin,Ciprofloxacin*, Ofloxacin, Lomefloxacin, Sparfloxacin, Gatifloxacin, Moxifloxacin
   2. Miscellaneous: Furazolidine, Nitrofurantoin*, Methanamine. 3
3. Antiviral agents: Amantadine hydrochloride, Rimantadine hydrochloride, Idoxuridine trifluoride, Acyclovir*, Gancyclovir, Zidovudine, Didanosine, Zalcitabine, Lamivudine, Loviride, Delavirding, Ribavirin, Saquinavir, Indinavir, Ritonavir. 4

UNIT IV 08

1. Antifungal agents:
   1. Antifungal antibiotics: Amphotericin-B, Nystatin, Natamycin, Griseofulvin.
   2. Synthetic Antifungal agents: Clotrimazole, Econazole, Butoconazole,Oxiconazole Tioconozole, Miconazole*, Ketoconazole, Terconazole, Itraconazole, Fluconazole, Naftifine hydrochloride, Tolnaftate*. 2
2. Anti-protozoal Agents: Metronidazole*, Tinidazole, Ornidazole, Diloxanide,Iodoquinol, Pentamidine Isethionate, Atovaquone, Eflornithine. 1
3. Anthelmintics: Diethylcarbamazine citrate*, Thiabendazole, Mebendazole*, Albendazole, Niclosamide, Oxamniquine, Praziquinal, Ivermectin 1
4. Sulphonamides and Sulfones: Historical development, chemistry, classification and SAR of Sulfonamides: Sulphamethizole, Sulfisoxazole, Sulphamethizine, Sulfacetamide*, Sulphapyridine, Sulfamethoxaole*, Sulphadiazine, Mefenide acetate, Sulfasalazine. Folate reductase inhibitors: Trimethoprim*, Cotrimoxazole Sulfones: Dapsone*.

UNIT V 07

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Reference Books (Latest Editions to be adopted)

1. Wilson and Giswolds Organic medicinal and Pharmaceutical Chemistry.
2. Foyes Principles of Medicinal Chemistry.
3. Burgers Medicinal Chemistry, Vol I to IV.
4. Introduction to principles of drug design- Smith and Williams.
5. Remingtons Pharmaceutical Sciences.
6. Martindales extra pharmacopoeia.
7. Organic Chemistry by I.L. Finar, Vol. II.
8. The Organic Chemistry of Drug Synthesis by Lednicer, Vol. 1-5
9. Indian Pharmacopoeia.
10. Text book of practical organic chemistry- A.I.Vogel.

For detail syllabus of all other subjects of Bachelor of Pharmacy (B.Pharm), 2019 regulation do visit B.Pharm 6th Sem Subjects syllabus for 2019 regulation.