BP402T: Medicinal Chemistry I – Theory Syllabus for B.Pharm 4th Sem 2019 Pattern Mumbai University

Medicinal Chemistry I – Theory detailed Syllabus Scheme for Bachelor of Pharmacy (B.Pharm), 2019 regulation has been taken from the University of Mumbai official website and presented for the Pharmacy students. For Course Code, Subject Name, Continuous Mode, SE Marks, SE Duration, Total, Marks, Duration in Hours, Total Marks, and other information, do visit full semester subjects post given below.

For all other Mumbai University B.Pharm 4th Sem Syllabus 2019 Pattern, do visit B.Pharm 4th Sem 2019 Pattern Scheme. The detailed syllabus scheme for medicinal chemistry i – theory is as follows.

BP402T: Medicinal Chemistry I – Theory Syllabus for B.Pharm 4th Sem 2019 Pattern Mumbai University

Scope:

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Objectives

Upon completion of the course the student shall be able to:

1. understand the chemistry of drugs with respect to their pharmacological activity
2. understand the drug metabolic pathways, adverse effect and therapeutic value of drugs
3. know the Structural Activity Relationship (SAR) of different class of drugs
4. write the chemical synthesis of some drugs

UNIT I – Introduction to Medicinal Chemistry 10

1. History and development of medicinal chemistry 1
2. Physicochemical properties in relation to biological action Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and Geometrical isomerism 4
3. Drug metabolism
   • Drug metabolism principles- Phase I and Phase II.
   • Factors affecting drug metabolism including stereo chemical aspects 5

UNIT II – Drugs acting on Autonomic Nervous System 10

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UNIT III – Cholinergic neurotranimitters 10

1. Biosynthesis and catabolism of acetylcholine. Cholinergic receptors (Muscarinic & Nicotinic) and their distribution 2
2. Parasympathomimetic agents: SAR of Parasympathomimetic agents
   • Direct acting agents: Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine.
   • Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible): Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.
   • Cholinesterase reactivator: Pralidoxime chloride. 4
3. Cholinergic Blocking agents: SAR of cholinolytic agents
   • Solanaceous alkaloids and analogues: Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.
   • Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*, Glycopyrrolate, Methantheline bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride. 4

UNIT IV – Drugs acting on Central Nervous System 08

1. Sedatives and Hypnotics:
   • Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem
   • Barbiturtes: SAR of barbiturates, Barbital*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital
   • Miscelleneous: Amides and imides:Glutethmide. Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol. Aldehyde & their derivatives: Triclofos sodium, Paraldehyde.
2. Antipsychotics
   • Phenothiazeines: SAR of Phenothiazeines – Promazine hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride.
   • Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine.
   • Fluro buterophenones: Haloperidol, Droperidol, Risperidone.
   • Beta amino ketones: Molindone hydrochloride.
   • Benzamides: Sulpieride. 3
3. Anticonvulsants: SAR of Anticonvulsants, mechanism of anticonvulsant action
   • Barbiturates: Phenobarbitone, Methabarbital.
   • Hydantoins: Phenytoin*, Mephenytoin, Ethotoin
   • Oxazolidine diones: Trimethadione, Paramethadione
   • Succinimides: Phensuximide, Methsuximide, Ethosuximide*
   • Urea and monoacylureas: Phenacemide, Carbamazepine*
   • Benzodiazepines: Clonazepam
   • Miscellaneous: Primidone, Valproic acid , Gabapentin, Felbamate 2

UNIT V- Drugs acting on Central Nervous System 07

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Reference Books (Latest Editions to be adopted)

1. Wilson and Giswolds Organic medicinal and Pharmaceutical Chemistry.
2. Foyes Principles of Medicinal Chemistry.
3. Burgers Medicinal Chemistry, Vol I to IV.
4. Introduction to principles of drug design- Smith and Williams.
5. Remingtons Pharmaceutical Sciences.
6. Martindales extra pharmacopoeia.
7. Organic Chemistry by I.L. Finar, Vol. II.
8. The Organic Chemistry of Drug Synthesis by Lednicer, Vol. 1-5
9. Indian Pharmacopoeia.
10. Text book of practical organic chemistry- A.I.Vogel.

For detail syllabus of all other subjects of Bachelor of Pharmacy (B.Pharm), 2019 regulation do visit B.Pharm 4th Sem Subjects syllabus for 2019 regulation.