{"id":1994,"date":"2016-08-07T11:05:45","date_gmt":"2016-08-07T11:05:45","guid":{"rendered":"http:\/\/www.inspirenignite.com\/jntuk\/?p=1994"},"modified":"2016-08-07T11:05:45","modified_gmt":"2016-08-07T11:05:45","slug":"jntuk-b-tech-biopharmaceutics-pharmacokinetics-for-r13-batch","status":"publish","type":"post","link":"https:\/\/www.inspirenignite.com\/jntuk\/jntuk-b-tech-biopharmaceutics-pharmacokinetics-for-r13-batch\/","title":{"rendered":"JNTUK B. Tech Biopharmaceutics &amp; Pharmacokinetics for R13 Batch."},"content":{"rendered":"<p>JNTUK B.Tech Biopharmaceutics &amp; Pharmacokinetics gives you detail information of Biopharmaceutics &amp; Pharmacokinetics R13 syllabus It will be help full to understand you complete curriculum of the year.<\/p><div class=\"a9916ad81d5189659b0bfae0b37c143c\" data-index=\"1\" style=\"float: none; margin:10px 0 10px 0; text-align:center;\">\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block; text-align:center;\"\r\n     data-ad-layout=\"in-article\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-client=\"ca-pub-1181153414625576\"\r\n     data-ad-slot=\"9648548092\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n\n<p><strong>UNIT &#8211; I<\/strong><br \/>\nIntroduction to Biopharmaceutics and Pharmacokinetics and their role in formulation development and clinical setting<br \/>\nBiopharmaceutics: Passage of drugs across biological barrier (passive diffusion, active transport, facilitated diffusion and pinocytosis) factors influencing absorption \u2013 physiochemical, physiological and pharmaceutical.<\/p>\n<p><strong>LO<\/strong> : To understandBiopharmaceutics, Pharmacokinetics and their applications \u2013absorption mechanisms, factors, their application with examples.<\/p>\n<p><strong>UNIT &#8211; II<\/strong><br \/>\nDrug distribution in the body, Factors influencing distribution. Plasma protein binding, binding sites, factors influencing protein binding<\/p>\n<p><strong>LO :<\/strong> To understand drug distribution, protein binding \u2013 factors.<\/p>\n<p><strong>UNIT &#8211; III : Pharmacokinetics<\/strong><br \/>\nSignificance of plasma drug concentration measurement. Compartment model: Definition and scope. Pharmacokinetics of drug absorption \u2013 Zero order and first order absorption rate constant using Wagner Nelson and Loo-riegelman method. Volume of distribution and distribution coefficient.<\/p>\n<p><strong>LO<\/strong> : To understand the significance of plasma drug concentrations, compartment models &#8211; kinetics, parameters.<\/p>\n<p><strong>UNIT &#8211; IV : Comparative kinetics<\/strong><br \/>\nOne compartment and two compartment models. Determination of Pharmacokinetic parameters from plasma and urine data after drug administration by oral parenteral and other routes. Curve fitting (Method of Residuals) Regression procedures. Clearance concept, Mechanism of Renal clearance, clearance ratio, determination of renal clearance. Non-linear pharmacokietics with special reference to one compartment model after I.V.Drug administration, MichalesMente Equation, detection of non-linearity (Saturation mechanism).<\/p>\n<p><strong>LO :<\/strong> To understand pharmacokinetic models, Linear and Non-Linear kinetics, mechanisms and method of assessments.<\/p>\n<p><strong>UNIT &#8211; V : Clinical pharmacokinetics Definition and scope<\/strong><br \/>\nDosage adjustment in patients with and without renal and hepatic failure. Pharmakokinetic drug interactions and its significance in combination therapy.<\/p>\n<p><strong>LO :<\/strong> To understand clinical pharmacokinetics and their significance, drug interactions \u2013 Adjustment of dose.<\/p>\n<p><strong>UNIT &#8211; VI : Bioavailability and Bioequivalance.<\/strong><br \/>\nMeasures of bioavailability, C-max, T-max and Area Under the Curve (AUC) Design of single dose bioequivalance study and relevant statistics.<br \/>\nOverview of regulatory requirements for conduction of bio-equivalence studies. Bio availability and bio equivalence including evaluation testing protocols.<br \/>\na. In vitro dissolution studies for solid dosage forms methods, interpretation of dissolution data in vitro, in vivo correlations.<br \/>\nb. Bioavailability testing protocol and procedures.<br \/>\nc. In vivo methods of evaluation \u2013 statistical treatment.<\/p>\n<p><strong>LO :<\/strong> To understand bioavailability, bioequivalence, concepts, assessments, design, regulation, invitro dissolution methods, Invitro-invivo correlation.<\/p>\n<p><strong>TEXT BOOKS<\/strong><\/p>\n<ul>\n<li>Venkateshulu, Fundamentals of Biopharmaceutics and Pharmacokinetics, Pharma Book Syndicate.<\/li>\n<li>Milo Gibaldi, Biopharmaceutics and clinical pharmacokinetics 4\/Edn. Pharma Book Syndicate.<\/li>\n<li>DM Brahmanka and SB Jaiswal, biophamaceutics and pharmacokinetics- a treatise, vallabhprakasham, Delhi.<\/li>\n<li>P.L. Madan, Biopharmaceuticas and Pharmacokinnetics, Jaypee Bros.<\/li>\n<\/ul>\n<p><strong>REFERENCES<\/strong><\/p>\n<ul>\n<li>Remington\u2019s pharmaceutical sciences, Mac Pub. Co., Easton Pensylvania.<\/li>\n<li>Modern pharmaceutics by banker Marcel Dekker Inc., NY<\/li>\n<li>L. lachman, H.A.Lieberman, JL. Kanig, the theory aad practice of industrial pharmacy, Varghese publ house, Mumbai.<\/li>\n<li>AR. Gennerio Remington: the science andpractice of pharmacy, vol 1 &amp; 2 Lippincott Williams &amp;wilkins, Philadelphia, 2004.<\/li>\n<li>Robert E notary, Biopharmaceutics and pharmacokinetics \u2013 an introduction, arceldekkerinc., NY<\/li>\n<li>L. Shargel and ABC Yu, textbook of applied biopharmaceutics&amp; pharmacokinetics, 4thedn, Appleton \u2013 centuary \u2013 crofts, Connecticut, 2004.<\/li>\n<\/ul>\n<p>For more information about all JNTU updates please stay connected to us on FB and don\u2019t hesitate to ask any questions in the comment.<\/p>\n<div class=\"a9916ad81d5189659b0bfae0b37c143c\" data-index=\"2\" style=\"float: none; margin:10px 0 10px 0; text-align:center;\">\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block; text-align:center;\"\r\n     data-ad-layout=\"in-article\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-client=\"ca-pub-1181153414625576\"\r\n     data-ad-slot=\"8060844699\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>JNTUK B.Tech Biopharmaceutics &amp; Pharmacokinetics gives you detail information of Biopharmaceutics &amp; Pharmacokinetics R13 syllabus It will be help full to understand you complete curriculum of the year. UNIT &#8211; [&hellip;]<\/p>\n","protected":false},"author":2259,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-1994","post","type-post","status-publish","format-standard","hentry","category-syllabus"],"_links":{"self":[{"href":"https:\/\/www.inspirenignite.com\/jntuk\/wp-json\/wp\/v2\/posts\/1994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.inspirenignite.com\/jntuk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.inspirenignite.com\/jntuk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.inspirenignite.com\/jntuk\/wp-json\/wp\/v2\/users\/2259"}],"replies":[{"embeddable":true,"href":"https:\/\/www.inspirenignite.com\/jntuk\/wp-json\/wp\/v2\/comments?post=1994"}],"version-history":[{"count":1,"href":"https:\/\/www.inspirenignite.com\/jntuk\/wp-json\/wp\/v2\/posts\/1994\/revisions"}],"predecessor-version":[{"id":1997,"href":"https:\/\/www.inspirenignite.com\/jntuk\/wp-json\/wp\/v2\/posts\/1994\/revisions\/1997"}],"wp:attachment":[{"href":"https:\/\/www.inspirenignite.com\/jntuk\/wp-json\/wp\/v2\/media?parent=1994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.inspirenignite.com\/jntuk\/wp-json\/wp\/v2\/categories?post=1994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.inspirenignite.com\/jntuk\/wp-json\/wp\/v2\/tags?post=1994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}