JNTUK B.Tech Pharmaceutical Organic Chemistry-I gives you detail information of Pharmaceutical Organic Chemistry-I R13 syllabus It will be help full to understand you complete curriculum of the year.
UNIT-I : Structure and reactivity of organic molecules: Polarity of bonds, electronic effects: electromeric effect, inductive effect, mesomeric effect and Hyperconjugation and their influence on the properties of organic molecules;
charged species: carbocations and carbanions, their generation, stabilities, rearrangement in the case of carbocations; Free radicals: formation and stability.
LO : Understanding the basic concepts influencing the reactivity of organic molecules, understanding the mechanisms wherever applicable, applications of the above in the interpretation of various properties of organic molecules.
UNIT-II : Alkanes and cycloalkanes: Nomenclature, general methods of preparation, chain and conformational isomerism in the case of alkenes and their relative stabilities, Bayer’s strain theory and Sachse-Mohr theory in the case of cycloalkanes and their limitations.
Alkenes: Nomenclature, general methods of preparation, characteristic electrophilic and free radical addition reactions, orientation of product formation as interpreted by Markonikov’s rule and peroxide effect (Anti-Markonikov’s rule), ozonolysis and allylic substitution.
Alkadienes: Nomenclature, stability of conjugated dienes, 1,2- and 1,4-reactions and their relative stabilities.
Alkynes: Nomenclature, general methods of preparation, characteristic reactions with emphasis on acidity of one alkynes, formation of metal acetylides, stereospecific reduction of alkynes and addition of water involving keto-enol tautomerism
LO : Structures, equations involved in the preparations, mechanism of formation or the reaction, rearrangements if any, discussion on stabilities and applications of the characteristic reactions in synthesis.
UNIT-III : Alkylhalides: Nomenclature, general methods of preparation, significance of nucleophilic subsititution of alkylhalides in organic synthesis, mechanisms and salient features of SN1 and SN2 reactions with examples including the proof in favor of these reactions, a comparison of SN1 and SN2, elimination
reactions (E1 and E2): mechanisms, salient features and orientation of product formation in terms of Saytzeff’s rule and Hoffmann orientation.
LO : Structures, equations involving the methods of preparations and reactions, stabilities and applications of the reactions.
UNIT-IV : Alcohols: Nomenclature, classification, methods of preparation, industrial synthesis of ethanol and methanol, reactions of alcohols involving the replacement of hydroxyl or replacement of the hydrogen of the hydroxyl, iodoform reaction and Lucas test.
Ethers: Nomenclature, Williamson’s synthesis, action of hydroiodic acid on ethers.
LO : Structures, general properties, equations involving the methods of preparation and reactions, mechanisms, reactivities.
UNIT-V : Stereo chemistry: Isomerism and its comparison to stereoisomerism, stereoisomers, optical isomers (enantiomers), characteristics of enantiomers (chirality), racemic mixtures, methods of separation of racemic mixtures,
optical activity, optical rotation, specific rotation, plane of symmetry and centre of symmetry, diastereomers, their properties and required characteristics with examples as given by Fischer projection formulae; mesoform and its characteristics; Configuration: relative configuration (D and L), absolute configuration (R and S); Geometric isomerism: cis-trans isomerism and E and Z nomenclature.
LO : Stereochemical structures, importance of stereochemistry with respect to drugs as interpreted in terms of reactivity and the properties of chiral drugs.
UNIT-VI : Grignard reagent: Preparation, characteristic nucleophilic addition and substitution reactions, applications in organic synthesis and limitations.
LO : Structure, mechanism and usefulness in synthesis.
TEXT BOOKS
- T.R. Morrison and R.N. Boyd, Organic chemistry, pentice hall of India private limited, New Delhi.
- Arun Bahl & Bahl, Advanced Pharmaceutical Organic Chemistry.
REFERENCES
- R.L Madan, Organic Chemistry.
- Lloyd N. Ferguson, Text book of Organic Chemistry, 2nd edition.
- Raj K Bansal, A textbook of Organic Chemistry, 5th edition.
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