JNTUK B. Tech Pharmaceutical Microbiology for R13 Batch.

JNTUK B.Tech Pharmaceutical Microbiology gives you detail information of Pharmaceutical Microbiology R13 syllabus It will be help full to understand you complete curriculum of the year.

UNIT – I : 10 Introduction to Microbiology: Origin, scope and discovery of spontaneous generations theory, contributions of Antony Von Leuwenhock, Pasteur, Koch and Lister.
Diversity of Microorganisms: Prokaryotes versus eukaryotes – eukaryotic and Prokaryotic cell structure, three domains of life (bacteria, archea and eurkaryotics). Pharmaceutical significance of protozoa, algae, fungi, bacteria and viruses. Characterisation and identification of microorganisms.
LO : To understand diversity of microorganisms and their spontaneous generation and use and harmful nature.

UNIT – II : 10 Nutrition and Growth of Microbes: Nutritional requirements, Types of Nutrient media and growth conditions and Nutritional types based on energy source. Isolation, cultivation (aerobic & anaerobic) and preservation of microorganisms, physiology of growth, bacterial growth curve, methods for determing bacterial numbers, mass and cell constitutents. Exponential growth and generation time.Bacterial growth in batch and continuous culture (chemostat and turbidostat) synchronous growth.
Microorganisms and their Environment: Effects and microbial adaptations to environmental conditions – Temperature, oxygen desiccation, extreme cold ionic effect, electricity, osmotic pressure, radiant energy, hydrostatic pressure, mechanical impact, vibration.
LO : To understand that bacterial growth curve consist of rapid growth followed by stabilization and later decline due to exhaustion of nutrients and several parameters affects the above.

UNIT –III: 08 Control of Microorganisms: General Concepts, Inhibition of growth and killing, sterilization and disinfection, antisepsis and sanitation, mode of action application & limitation of physical agents (moist and dry heat, radiation and filtration), chemical agents. Various types of disinfectants, factors affecting sterilization and disinfection, evaluation of antimicrobial
activity. Chemotherapeutic agents, mode of action and applications, drug resistance. Official methods of sterility testing of pharmaceuticals and biosafety measures.
LO : To understand that moist heat, dry heat,radiation,filtration,chemicals can be used for sterilization and disinfection to provide aseptic condition in the filling areas, operation theatres etc

UNIT –IV :10 : Bacterial Genetics: Genetic recombination in bacteria, DNA replication, transcription and translation. Gene regulation (lac operon and tryptophan operon).Mutagenesis, chemical and physical mutagens.
LO : To understand the concept of bacterial resistance to antibiotics and other conditions.

UNIT – V : 04 Epidemiology of Diseases: Study of etiology, diagnosis, source of infection, mode of transmission, immunization methods, prevention and control of the following diseases. Bacillary dysentery, diphtheria, tuberculosis, leprosy, cholera, typhoid, syphilis, gonorrhea, tetanus, food poisoning and infection hepatitis.
LO: To understand that microbes are responsible for causing certain diseases.

UNIT – VI : 08 Application of Microbes in Pharmaceutical Industry
a.Microbiological Assays: Principles and Methods involved in Assay of Antibiotics, Vitamins, Amino acids & Bio-Sensors in Analysis.

b. Microbial Source & applications of various pharma products like Antibiotics,
Vitamins, amino acids, solvents, enzymes & genetic engineered products etc.
LO : To understand that antibiotics/Vitamins can be standardized by microbial assays. And some useful products can be produced as a bacterial metabolites.

TEXT BOOKS

• Pelczar and Reid, Text Book of Microbiology.
• Anantha Narayan and Jayram Panikar, Text Book of Microbiology, Orient Longman, Delhi.
• N.K. Jain, Pharmaceutical Microbiology.
• Alcamo, Microbiology.

REFERENCES

• Heritage. J, Introductory Microbiology.
• Nester, Anderson, Roberts, Pearsall, Microbiology, McGraw-Hill.
• Hugo,W B Pharmaceutical Microbiology.
• Tortora A. Gerard, Text Book of Microbiology.

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