JNTUK B.Tech Pharm. Organic Chemistry – II gives you detail information of Pharm. Organic Chemistry – II R13 syllabus It will be help full to understand you complete curriculum of the year.
UNIT-I : Benzene: Kekule’s structure, aromaticity, Huckle’s rule, resonance energy, characteristic electrophilic substitution reactions: nitration, halogenations, sulfonation, Friedel-Craft’s alkylation and acylation with limitations, orientation in monosubstituted benzenes.
Polynuclear aromatic hydrocarbons: Nomenclature, methods of preparation of naphthalene, anthracene and phenanthrene, their oxidation and reduction reactions, relative susceptibilities to oxidation as interpreted in terms of sacrifice of resonance energies, electrophilic substitution reactions.
Arylhalides: Nomenclature, comparison of reactivity with respect to alkylhalides, mechanism of nucleophilic substitution (Benzyne concept).
LO : Understanding the properties of aromatic compounds, mechanisms of reactions and their usefulness in organic synthesis, electronic factors influencing orientation.
UNIT-II : Carbonyl compounds: Nomenclature, important methods of preparation, characteristic nucleophilic addition reactions (addition of bisulphate, Grignard reagent, hydrogen cyanide, hydrazine derivatives and alcohols); Aldol condensation, Cannizzaro reaction and Perkin reaction.
LO : General properties, relative reactivities towards nucleophilic addition, mechanisms and applications.
UNIT-III : Carboxylic acids: Nomenclature, important methods of preparation, characteristic reactions (acidity, relative acidities, reduction, H-V-Z reaction, conversion into acid chlorides, amides and esters); methods of preparation of important esters (acetoacetic ester and malonic ester) and their applications in organic synthesis.
LO : General properties, measurement of relative acidities, equations involving the reactions and mechanisms, applications in synthesis.
UNIT-IV : Phenols: Nomenclature, general methods of preparation, industrial synthesis of phenol by Dow process, characteristic reactions (acidity and its comparison to alcohols and carboxylic acids as interpreted by resonance, ether formation, ester formation, Kolbe reaction, Reimer-Tiemann Reaction, bromination and nitration).
LO : Structures, equations, mechanisms, importance of these reactions in pharmaceutical organic synthesis.
UNIT-V : Amines and Diazonium compounds: Nomenclature, methods of preparation, characteristic reactions (basicity and relative basicities, alkylation and exhaustive alkylation, nitration and orientation), separation of all three classes of amines by Hinsberg’s method; formation of Diazonium compounds, characteristic reactions (replacement by hydrogen, Sandmeyer reaction, replacement by nitrile, and their applications in synthesis and coupling reactions).
LO : Properties, structures, equations, mechanisms, orientations and applications.
UNIT-VI : Name reactions: Beckmann rearrangement, Mannich reaction, Fries rearrangement, Michael addition, Schmidt reaction, Benzoin condensation.
LO : General reaction, structures and mechanism, applications in organic synthesis.
TEXT BOOKS
- T.R.Morrison and R.N.Boyd, Organic chemistry, pentice hall of India private limited, New Delhi.
- Arun Bahl & Bahl, Advanced Pharmaceutical Organic Chemistry.
REFERENCES
- R.L Madan, Organic Chemistry.
- Lloyd N. Ferguson, Text book of Organic Chemistry, 2nd edition,.
- Raj K Bansal, A textbook of Organic Chemistry, 5th edition.
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