JNTUK B.Tech Pharm. Biotechnology gives you detail information of Pharm. Biotechnology R13 syllabus It will be help full to understand you complete curriculum of the year.
UNIT – I
Fermentation Technology: Isolation, Selection, Screening of Industrial important microbes, Strain improvement. Types, design & operation of Bioreactor. Types of fermentations, optimization of fermentation process, Principle and Procedure involving in downstream process and effluent treatment.
LO : To understand principles of fermentation technology- types of bioreactor – optimization of fermentation process – principles of effluent treatment.
UNIT – II
Specific Fermentations: Selection of organism, fermentation & purification of various antibiotics, vitamins, aminoacids, organic acids, solvents like Penicillin, Streptomycin, Tetracycline, Erythromycin, Riboflavin, Cynacobalamin, Glutamic Acid, Lysin, Citric Acid, Lactic Acid, Alcohol, Acetone etc.
LO : To understand Fermentations of various types of industrial and medicinal compounds.
UNIT – III
Microbial Transformations: Types, Methods of bioconversions & Application in Pharma Industry, Steroidal transformation.
Recombinant DNA Technology: Introduction to R-DNA technology and genetic engineering, steps involved, isolation of enzymes, vectors, recombination and cloning of genes. Production of bio technology derived therapeutic proteins like humulin, humatrop, activase, intron a, monoclonal antibodies by hybridoma technique, recombivax HB (Hepatitis B).
LO : To understand types, methods and applications of bioconversion – principles and production technology of recombinant DNA technology with examples.
UNIT – IV
Immunology & Immunological Preparations: Principles of Immunity, Humoral immunity, cell mediated immunity, antigen – antibody reactions, hypersensitivity and its applications. Active & passive immunizations vaccine preparation, standardization & storage of BCG, cholera, smallpox, polio, typhus, tetanus toxoide, immuno serum & diagnostic agents.
LO : To understand principles of Immunology, Antigen- Antibody reactions – applications, active and passive immunizations – study of various vaccines and sera.
UNIT – V
Enzyme Technology: Techniques of immobilization of enzymes, factors affecting enzyme kinetics, advantages of immobilization over isolated enzymes. Study of enzymes such as hyaluronidas, penicillinase, streptokinase, streptodornase, amylase, protease etc. immobilization of bacteria & plant cells.
LO : To understand techniques, applications and productions enzymes of medicinal importance.
UNIT – VI
Introduction, role, collection, process & storage of blood products, plasma substitutes and sutures & ligatures like whole human blood, human normal eg, dextran, catgut etc. Introductory study & applications of bioinformatics, proteomics and genomics.
LO : To understand Blood products – collection processing, storage and uses of various blood products.
TEXT BOOKS
- Wulf Crueger and Anneliese Crueger, Biotechnology, 2nd Ed, Publ-Panima publication co-operation, New Delhi.
- P. F. Stanbury & A. Whitaker, Principles of fermentation technology, Pergamon Press
- B.P. Nagori & Roshan Issari, Foundations in Pharmaceutical Biotechnology
- Sambamurthy. K, Text Book of Pharmaceutical Biotechnology.
- S. S. Kori, Pharmaceutical biotechnology.
REFERENCES
- Prescott and Dunne, “Industrial Microbiology” MC Caraw Hill Bool Company.
- Peppler “Microbial Technology” Vol. 1 & 2.
- K. Kielsliched “Biotechnology” Vol 6, Verlegchemic, Switzerland.
- PF Standury & A. Whitaker, “Principles of fermentation Technology” Pergamon Press.
- OP Ward” Fermentation Technology, Principles, Processes products” Open University press, Milton Keynes, UK.
- A. M. Campbelli, Monoclinical antibody technology.
- A. Wiseman, Handbook of enzyme biotechnology. J. D. Watson, Recombinant DNA technology.
- Smith and Hood, Molecular biology and biotechnology.
- E.A. Rawlins, Bentley’s, A text book of pharmaceutics, 8th Ed, 1982 Bailler Tindall & Co.
- Alexander N. Glazer & Hiroshi Nikaido, Microbial biotechnology, W. H. Freeman Co.
- Ahwood.T.K, Introduction to Bio Informatics.
- Cassida, Industrial microbiology.
- H.K. Das, Textbook of Biochemistry.
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