JNTUK B.Tech Medicinal Chemistry – III gives you detail information of Medicinal Chemistry – III R13 syllabus It will be help full to understand you complete curriculum of the year.
UNIT I
A general introduction to advances in medicinal chemistry with emphasis on the principles of combinatorial chemistry, high throughput screening and QSAR studies.
LO : General concepts, principles, procedures, advantages, equations and methodologies.
UNIT II
1. Types of receptors, interaction forces
2. Preliminary aspects of molecular modeling studies: docking, pharmacophore modeling
LO : General concepts, principles, procedures, advantages and methodologies.
UNIT III
1. Steroidal anti-inflammatory agents: classification, structures, SAR, uses and toxicity
2. Bile acids: classification, structures and functions
3. Estrogens and Progesterone: structures, functions, interconversion of estrogens, uses of natural and synthetic estrogens, synthesis of Progesterone from Diosgenin.
LO : Acquaintance with steroidal structures, features, properties, uses, mode of action.
UNIT IV
1. Antiarrhythmics: classification, mode of action, uses and synthesis of Procainamide.
2. Cardiac glycosides: classification, structures and structural features, mode of action and therapeutic uses.
LO : Introduction to cardiovascular diseases, uses, mode of action.
UNIT V
1. Antihypertensives: classification, mode of action, SAR, currently used drugs and synthesis of Methyldopa, Clonidine, Losartan.
2. Antianginals and coronary vasodilators: classification, mode of action, SAR and uses, synthesis of Isosorbide dinitrate.
LO : Introduction to cardiovascular diseases, uses, mode of action.
UNIT VI
1. Diuretics: Definition, classification, mode of action, SAR of different classes, uses and synthesis of Acetazolamide, Ethacrynic acid and Hydrochlorthiazide.
LO : Introduction, structures, methodology of synthesis, advantages.
TEXT BOOKS
- William O. Foye, Textbook of Medicinal Chemistry by, Lea Febiger, Philadelphia.
- JM Beale, Wilson & Giswold’s Textbook of organic Medicinal Chemistry and pharmaceutical chemistry by (Eds), 11th Ed, Lipcott, Raven, Philadelphia, 2004.
- S. N. Pandeya, Textbook of mediacinal chemistry, SG Publ. Varanasi, 2003.
REFERENCES
- D. Abraham (Ed), Burger Medicinal chemistry ad Drug discovery, Vol. 1 & 2. John Wiley & Sons, New York 2003, 6th Ed.
- Lippincott Williams and Wilkins: Remington Pharmaceutical Sciences
- L. M. Atherden, Bentley and Driver’s Textbook of Pharmaceutical Chemistry. Oxford University Press, Delhi.
- B.N. Lads, MG.Mandel and F.I. way, Fundamentals of drug metabolism & disposition, William & welking co, Baltimore USA.
- C. Hansch, Comprehensive medicinal chemistry, Vol 1 – 6 Elsevier pergmon press, oxford
- Daniel lednicer, Strategies For Organic Drug Synthesis And Design, John Wiley, N. Y. 1998.
- D. Lednicer, Organic drug synthesis, Vol, 1 – 6, J.Wiley N.Y.
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