JNTUK B.Tech Medicinal Chemistry – II gives you detail information of Medicinal Chemistry – II R13 syllabus It will be help full to understand you complete curriculum of the year.
UNIT – I
- Introduction to principles of chemotherapy, chemotherapeutic index, drug resistance.
- Sulphonamides: Sulfisoxazole, Sulphamethazole and Sulphathiazole.
- Antitubercular agents: PASA, Isoniazid, Ethambutol
- Antileprotic agents: Dapsone
LO : Definition, current status, classification, mode of action, Structure-Activity Relationship (SAR) wherever applicable, therapeutic uses and synthesis of compounds as given above under each class.
UNIT – II
- Antimalarials: Chloroquine, Primaquine and Pyrimethamine
- Anthelmintics: Diethyl Carbamazine Citrate, Mebendazole, Tinidazole,
- Antiamoebic agents: Metronidazole and Diloxanide furoate.
- Antifungal agents: Clotrimazole, Fluconazole and Tolnaftate.
LO : Definition, current status, classification, mode of action, Structure-Activity Relationship (SAR) wherever applicable, therapeutic uses and synthesis of compounds as given above under each class.
UNIT – III
- Antiviral agents: Acyclovir, Zidovudine, Idoxuridine and Amantadine.
- Cytostatic agents: Chlorambucil, Cyclophospamide, Carmustine, 5-Flouro Uracil and Mercaptopurine
LO : Definition, current status, classification, mode of action, Structure-Activity Relationship (SAR) wherever applicable, therapeutic uses and synthesis of compounds as given above under each class.
UNIT – IV Antibiotics:
- Penicillins: Ampicillin, Amoxycillin
- Cephalosporins: structures of important Cephalosporins (not synthesis)
- Tetracyclins: Oxytetracycline, Doxycycline
- Aminoglycosides: Streptomycin and Neomycin (structures).
- Miscellaneous: Chloramphenicol, Rifampicin (only structure)
LO : Chemistry, structures of currently used drugs, classification, mode of action, Structure-Activity Relationship (SAR) wherever applicable, therapeutic uses and synthesis of compounds as given above under each class.
UNIT – V
- Water soluble vitamins: structures of B1, B2, B6, B12, Nicotinic acid,
- Nicotinamide, Folic acid and Ascorbic acid.
LO : Chemistry, structural features, classification, mode Structure-Activity Relationship (SAR) wherever therapeutic uses, biological role. of action, applicable,
UNIT – VI
Fat soluble vitamins: structures of Vitamin A, Retinoic acid, Vitamin D, Ergosterol
LO: Chemistry including reactions, structural features, interconversions, classification, mode of action, Structure-Activity Relationship (SAR) wherever applicable, therapeutic uses, biological role.
TEXT BOOKS
- William O. Foye, Textbook of Medicinal Chemistry, Lea & Febiger, Philadelphia.
- JH Block & JM Beale, Wilson & Giswold’s Text book of organic Medicinal Chemistry and pharmaceutical chemistry by (Eds), 11th Ed, Lipincott, Raven, Philadelphia, 2004.
- S. N. Pandeya, Textbook of medicinal chemistry, SG Publ. Varanasi, 2003.
- Sri Ram, Medicinal Chemistry.
- Rama Rao Nadendla, Medicinal Chemistry.
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