JNTUK B.Tech Medicinal chemistry – I gives you detail information of Medicinal chemistry – I R13 syllabus It will be help full to understand you complete curriculum of the year
UNIT-I
Heterocyclic compounds:
1. Five and six membered ring systems with heteroatoms: Furan, pyrrole, thiophene, pyridine, imidazole, pyrazole, oxazole, isoxazole, thiazole and pyrimidine.
2. Fused ring systems with heteroatoms: Quinolines, isoquinolines, acridine, benzimidazole and phenothiazine.
LO : Nomenclature (numbering), one or two methods of preparation, important reactions, mechanisms and examples of drugs having the above ring systems.
UNIT-II
1. Drug activity and physico-chemical properties: solubility, partition coefficient, hydrogen bonding, chelation, surface activity, bioisosterism, optical and geometrical isomerism, prodrugs and soft drugs.
2. Mechanism of drug action: receptor theories, enzyme stimulation and enzyme inhibition.
3. Drug metabolism: Phase I and Phase II reactions, factors affecting drug metabolism.
LO : Concepts involving receptors, drug-receptor interaction forces, mechanisms, equations, structures, advantages.
UNIT-III
Drugs acting on CNS:
1. Hypnotics and anxiolytics: Phenobarbital, diazepam and alprazolam.
2. Antipsychotics: chlorpromazine and haloperidol.
3. Antiepileptics: phenytoin, carbamazepine, valproate sodium.
4. Antidepressants: imipramine, amitriptyline, Isocarboxazide, iproniazide.
5. General anaesthetics: ketamine, halothane and thiopental sodium.
LO : Definition, scope, classification, mode of action, Structure-Activity Relationship (SAR) wherever applicable, therapeutic uses and synthesis of compounds as given above under each class.
UNIT-IV
1. Adrenergic drugs: Amphetamine, salbutamol, ephedrine, phenylephrine and dopamine.
2. Adrenergic blockers: Prazosine, tolazoline, Propranolol, atenolol
3. Cholinergic drugs: Carbachol, bethanichol.
4. Anticholinergics: propantheline, dicyclomine.
5. Neuromuscular blockers: succinyl choline.
LO : Definition, scope, classification, mode of action, Structure-Activity Relationship (SAR) wherever applicable, therapeutic uses and synthesis of compounds as given above under each class.
UNIT-V
1. Analgesics and Non-steroidal anti-inflammatory agents (NSAIDs): paracetamol, aspirin, ibuprofen, indomethacin, diclofenac.
2. Narcotic analgesics : mepridine, methadone.
3. Local anaesthetics : benzocaine, procaine, lignocaine and dibucaine
LO : Definition, scope, classification, mode of action, Structure-Activity Relationship (SAR) wherever applicable, therapeutic uses and synthesis of compounds as given above under each class, an understanding of morphinans, its agonists and antagonists.
UNIT-VI
1. Oral antihyperglycemic agents: tolbutamide, gliclazide, glipizide, glibenclamide, metformin and pioglitazone.
2. Thyroid drugs: methimazole, propylthiouracil.
3. H1-receptor antagonists: diphenhydramine, chlorpheniramine, chlorcyclizine, cetrizine.
4. H2-receptor antagonists: ranitidine
5. Proton pump inhibitors: Omeprazole, rabeprazole, lansaprazole.
LO : Definition, scope, classification, mode of action, Structure-Activity Relationship (SAR) wherever applicable, therapeutic uses and synthesis of compounds as given above under each class, an understanding of morphinans, its agonists and antagonists.
TEXT BOOKS
- William O. Foye, Textbook of Medicinal Chemistry, Lea Febiger, Philadelphia.
- JH Block & JM Beale (Eds), Wilson & Giswold’s Text book of organic Medicinal Chemistry and pharmaceutical chemistry, 11th Ed, Lipcott, Raven, Philadelphia, 2004.
- S. N. Pandeya, Textbook of mediacinal chemistry, SG Publ. Varanasi, 2003.
- Rama Rao Nadendla, Medicinal Chemistry.
REFERENCES
- D. Abraham (Ed), Burger Medicinal chemistry ad Drug discovery, Vol. 1 & 2. John Wiley & Sons, New York 2003, 6th Ed.
- Lippincott Williams and Wilkins, Remington Pharmaceutical Sciences; 20th Edition.
- M. Atherden, Bentley and Driver’s Textbook of Pharmaceutical Chemistry Ed: l. Oxford University Press, Delhi.
- B.N. Lads, MG.Mandel and F.I. way, Fundamentals of drug metabolism & disposition, William & welking co, Baltimore USA.
- C. Hansch, Comprehensive medicinal chemistry, Vol 1 – 6 Elsevier pergmon press, Oxford.
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